Ku70*

Protein Ku70* map

Identifiers
X-ray repair complementing defective repair in Chinese hamster cells 6
HUGO:XRCC6 HGNC:4055 ENTREZ:2547 UNIPROT:P12956 GENECARDS:XRCC6 REACTOME:58273 KEGG:2547 ATLASONC:XRCC6ID246ch22q13 WIKI:XRCC6

Maps_Modules
 Apoptosis  map  / MITOCH_METABOLISM  map
 Apoptosis  map  / MOMP_REGULATION  map
 DNA repair  map  / C_NHEJ  map

References
synonym:Ku70
PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258,
PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180
Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ
PMID:17088286

Ku70*|​K539_ace|​K542_ace@Nucleus

References
a_re472( Apoptosis  map ):
PMID:15205477
in 293T cells Sirt1 attenuates BAX mediated apoptosis by deacetylating Ku70
identification of acetylation sites on Ku70 by use of synthetic acetylated peptides

Ku70*@Cytoplasm

References
a_re19( Apoptosis  map ):
PMID:12652308
in HEK293
Ku70 KO in MEFs results in hypersensitivity to apoptosis

Ku70*@Nucleus

References
a_re472( Apoptosis  map ):
PMID:15205477
in 293T cells Sirt1 attenuates BAX mediated apoptosis by deacetylating Ku70
identification of acetylation sites on Ku70 by use of synthetic acetylated peptides

Ku70*@default

References
d_re79:( DNA repair  map ) PMID:19772495
d_re566( DNA repair  map ):
Binding between Ku70/80/DNA-PK and WRN inhibits Ku activity
PMID:17303082
PMID:12202749
WRN is a key activator of alt_NHEJ pathway
PMID:18524993
C_NHEJ and A_NHEJ are competing mechanisms
PMID:24050180


Modifications:
In compartment: Cytoplasm
  1. Ku70*@Cytoplasm map

In compartment: Nucleus

  1. Ku70*@Nucleus map

  2. Ku70*|​K539_ace|​K542_ace@Nucleus map

In compartment: default

  1. Ku70*@default map

Participates in complexes:
In compartment: Nucleus

  1. Ku70*:​Ku80*@Nucleus map

  2. DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map
  3. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map
  4. APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map

In compartment: default

  1. Ku70*:​Ku80*:​Securin*@default map

Participates in reactions:
As Reactant or Product:

  1. BAX@Cytoplasm map + Ku70*@Cytoplasm map map a_s99

  2. Ku70*|​K539_ace|​K542_ace@Nucleus map map Ku70*@Nucleus map
  3. Ku70*@Nucleus map map Ku70*@Cytoplasm map
  4. Ku70*:​Ku80*@Nucleus map + Securin*@default map map Ku70*:​Ku80*:​Securin*@default map
  5. Ku80*@default map + Ku70*@default map + WRN@Nucleus map + DNA-PK*@default map map DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map
  6. Ku70*@default map + Ku80*@default map map Ku70*:​Ku80*@Nucleus map
  7. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map + LIG4:​XLF*:​XRCC4|​hm2@default map + PARP3@Nucleus map + DNA-PK*|​hm2|​active@default map + Ku80*@default map + Ku70*@Nucleus map + APLF@Nucleus map map APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map
  8. DNA-PK*|​hm2|​active@default map + Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map + Ku70*:​Ku80*@Nucleus map + PARP3@Nucleus map map Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map

As Catalyser:

  1. gA_NHEJ_DNA_st1*@Nucleus map map gA_NHEJ_DNA_st2*@Nucleus map

  2. gC_NHEJ_DNA_st1*@Nucleus map map gC_NHEJ_DNA_st2*@Nucleus map
  3. gC_NHEJ_DNA_st3*@Nucleus map map gC_NHEJ_DNA_st4*@Nucleus map
  4. gC_NHEJ_DNA_st4*@Nucleus map map gC_NHEJ_DNA_st5*@Nucleus map

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