s_mpk1_re29( Survival ):
Docking of activated ERK to the KSR1 scaffold negatively regulates the interaction between KSR1 and B-Raf.
s_mpk1_re35( Survival ):
RasGTP interacts with IMP cleaving it from KSR1. In this way KSR1 can play its role of scaffolding protein for ERK cascade.
Ras activation causes the cleavage of 14-3-3 from KSR1 (not modelled) exposing the membrane-targeting C1 domain as well as the docking site for ERK1/2.
s_mpk1_re189( Survival ):
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
s_mpk1_re15( Survival ):
After having translocated to the plasma membrane KSR1 is able to interact with activated B-Raf and ERK.
Participates in complexes:
In compartment: Cytoplasm
Participates in reactions:
As Reactant or Product:
- BRAF|pho:GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane + KSR1:MEK*@Cytoplasm → BRAF|pho:GRB2:KSR1:MEK*|pho|pho:RAS*|pho:RTK*:SOS*@Plasma Membrane
- ERK*|pho|pho:KSR1:MEK*|pho|pho@Cytoplasm → KSR1:MEK*@Cytoplasm + ERK*@Cytoplasm
- BRAF|pho:ERK*|pho|pho:GRB2:KSR1:MEK*|pho|pho:RAS*|pho:RTK*:SOS*@Plasma Membrane → KSR1:MEK*@Cytoplasm + BRAF|pho:GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane + ERK*|pho|pho@Cytoplasm
- IMP*:KSR1:MEK*@Cytoplasm → IMP*@Cytoplasm + KSR1:MEK*@Cytoplasm