JUN

Protein JUN map

Identifiers
Jun
HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN
jun proto-oncogene
“jun oncogene” “v-jun avian sarcoma virus 17 oncogene homolog” “v-jun sarcoma virus 17 oncogene homolog (avian)”

Maps_Modules
 Survival  map  / HEDGEHOG  map
 Survival  map  / MAPK  map
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:17439715
PMID:8545107
Jun proto-oncogene
AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers.
PMID:11274345

JUN@Nucleus

References
s_mpk1_re178( Survival  map ):
JNKs are the dominant kinases responsible for stress- and TNF-activated C-JUN phosphorylation.
PMID:11274345
s_wnc3_re5:( Survival  map ) PMID:15657420
s_wnc3_re31( Survival  map ):
Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription
PMID15657416
Not sure if dissociation of calcineurin and ERK/MEK occurs

JUN|​pho@Nucleus

References
s_mpk1_re178( Survival  map ):
JNKs are the dominant kinases responsible for stress- and TNF-activated C-JUN phosphorylation.
PMID:11274345
s_mpk1_re172( Survival  map ):
AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers.
s_mpk1_re187( Survival  map ):
JNK pathway negatively regulates ERK pathway by uncoupling ERK activation from MEK via activation of JUN transcriptional activity.
A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
PMID:12738796 PMID:18039929
s_s_mpk1_re172( Survival  map ):

JUN|​pho|​pho@Nucleus

References
s_wca3_re169( Survival  map ):
Upon WNT3a stimulation formation complex DVL with c-jun
PMID:18347071

JUN@Nucleus

Maps_Modules
 Survival  map  / WNT_NON_CANONICAL  map

References
cJun, JunB and JunD bind to AP-1 regulatory elements
PMID:11402342


Modifications:
In compartment: Nucleus
  1. JUN@Nucleus map

  2. JUN@Nucleus map
  3. JUN@Nucleus map
  4. JUN|​pho@Nucleus map
  5. JUN|​pho|​pho@Nucleus map
  6. JUN|​S63_pho|​S73_pho|​active@Nucleus map

Participates in complexes:
In compartment: Nucleus

  1. FOS|​pho:​JUN|​pho@Nucleus map

  2. ATF2|​pho:​JUN|​pho@Nucleus map
  3. DVL*:​JUN|​pho|​pho@Nucleus map
  4. JUN|​S63_pho|​S73_pho:​promoter_region@Nucleus map
  5. JUN|​S63_pho|​S73_pho:​promoter_region@Nucleus map
  6. GLI1|​pho|​pho:​JUN|​S63_pho|​S73_pho:​promoter_region@Nucleus map
  7. AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map
  8. BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  9. BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map
  10. BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  11. BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_emp|​ace|​ace@Nucleus map
  12. APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. JUN|​pho@Nucleus map + ATF2|​pho@Nucleus map map ATF2|​pho:​JUN|​pho@Nucleus map

  2. JUN|​pho@Nucleus map map s_s_mpk1_s1051
  3. JUN|​pho@Nucleus map + FOS|​pho@Nucleus map map FOS|​pho:​JUN|​pho@Nucleus map
  4. JUN@Nucleus map map JUN|​pho@Nucleus map
  5. MAPK pathway@Cytoplasm map map JUN|​S63_pho|​S73_pho|​active@Nucleus map
  6. JNK pathway@Cytoplasm map map JUN|​S63_pho|​S73_pho|​active@Nucleus map
  7. JUN|​S63_pho|​S73_pho|​active@Nucleus map + gpromoter_region@Nucleus map map JUN|​S63_pho|​S73_pho:​promoter_region@Nucleus map
  8. GLI1|​pho|​pho@Nucleus map + gpromoter_region@Nucleus map + JUN|​S63_pho|​S73_pho|​active@Nucleus map map GLI1|​pho|​pho:​JUN|​S63_pho|​S73_pho:​promoter_region@Nucleus map
  9. gpromoter_region@Nucleus map + JUN|​S63_pho|​S73_pho|​active@Nucleus map map JUN|​S63_pho|​S73_pho:​promoter_region@Nucleus map
  10. APC|​T1487_pho:​CTBP*|​hm2:​HDAC1_2*@Nucleus map + BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  11. APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map + CTBP*:​p300*@Nucleus map + CTBP*:​HDAC1_2*:​LEF_TCF*:​WRE*@Nucleus map + DVL*:​JUN|​pho|​pho@Nucleus map
  12. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus map + BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map map BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_emp|​ace|​ace@Nucleus map + HDAC1_2*:​TLE*|​ubi@Nucleus map
  13. JUN|​pho|​pho@Nucleus map + DVL*@Nucleus map map DVL*:​JUN|​pho|​pho@Nucleus map
  14. BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map + DVL*:​JUN|​pho|​pho@Nucleus map map BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  15. DVL*:​JUN|​pho|​pho@Nucleus map + BCL9:​CBP*|​S92_pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map map BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map
  16. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus map + BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map + HDAC1_2*:​TLE*|​ubi@Nucleus map
  17. JNK pathway@Cytoplasm map map JUN@Nucleus map
  18. JUN@Nucleus map map Transcription@Nucleus map
  19. JUN@Nucleus map map Growth arrest@Nucleus map
  20. JUN@Nucleus map map DNA repair@Nucleus map
  21. JUN@Nucleus map map Cell death@Nucleus map
  22. JUN@Nucleus map map Proliferation@Nucleus map
  23. MAPK pathway@Cytoplasm map map JUN@Nucleus map
  24. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map + gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map map AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map + CNA*:​CNB*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map
  25. gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map + NFAT*@Nucleus map map AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map

As Catalyser:

  1. ERK*|​pho|​pho@Cytoplasm map map ERK*@Cytoplasm map

  2. ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map map KSR1:​MEK*@Cytoplasm map + ERK*@Cytoplasm map
  3. ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map map MEK*:​SEF*@Cytoplasm map + ERK*@Cytoplasm map
  4. ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map map MEK*:​_beta_-Arrestin2*@Cytoplasm map + ERK*@Cytoplasm map
  5. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map + ERK*@Cytoplasm map + RAF1@Cytoplasm map
  6. gFOXA2@Nucleus map map rFOXA2@Nucleus map
  7. gJAG2@Nucleus map map rJAG2@Nucleus map
  8. gCyclinD*@Nucleus map map rCyclinD*@Nucleus map
  9. gJUN@Nucleus map map rJUN@Nucleus map
  10. gIL1R2@Nucleus map map rIL1R2@Nucleus map
  11. gS100A9@Nucleus map map rS100A9@Nucleus map
  12. gARC@Nucleus map map rARC@Nucleus map
  13. gULK1@Nucleus map map rULK1@Nucleus map
  14. gGenes under control of _br_CBP-mediated transcription*@Nucleus map map rRNA@Nucleus map
  15. gTCF4@Nucleus map map rTCF4@Nucleus map
  16. gRAD6B*@Nucleus map map rRAD6B*@Nucleus map
  17. gBCL9@Nucleus map map rBCL9@Nucleus map
  18. gMIR372@Nucleus map map arMIR372@Nucleus map
  19. gMIR373@Nucleus map map arMIR373@Nucleus map
  20. gIRS2@Nucleus map map rIRS2@Nucleus map
  21. gCRIPTO-1*@Nucleus map map rCRIPTO-1*@Nucleus map
  22. gMYC@Nucleus map map rMYC@Nucleus map
  23. gGene under control of_br_ P300-mediated transcription*@Nucleus map map rRNA@Nucleus map
  24. gGPC6@Nucleus map map rGPC6@Nucleus map

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