JNK*

Protein JNK* map

Identifiers
mitogen-activated protein kinase 8
JNK1
HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 GENECARDS:MAPK8 REACTOME:59293 KEGG:5599 ATLASONC:JNK1ID196 WIKI:MAPK8
mitogen-activated protein kinase 9
JNK2
HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 GENECARDS:MAPK9 REACTOME:59295 KEGG:5601 ATLASONC:JNK2ID426 WIKI:MAPK9
mitogen-activated protein kinase 10
JNK3
HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 GENECARDS:MAPK10 REACTOME:59297 KEGG:5602 ATLASONC:JNK3ID427 WIKI:MAPK10
JNK1, mitogen-activated protein kinase 8
JNK2, mitogen-activated protein kinase 9
JNK3, mitogen-activated protein kinase 10
PRKM8
PRKM9
PRKM10

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / MOMP_REGULATION  map
 Apoptosis  map  / TNF_RESPONSE  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 Survival  map  / MAPK  map
 Survival  map  / WNT_NON_CANONICAL  map

References
synonym:JNK1
synonym:JNK2
synonym:JNK3
PMID:21438496, PMID:21372320, PMID:19591900, PMID:17496919, PMID:15611655, PMID:8608010, PMID:20512932, PMID:20220133, PMID:20054826,
PMID:19616017

JNK*@Nucleus

References
e_re1186( EMT  map ):
PMID:21502402
Phosphorylation of serine 68 of Twist1 stabilizes Twist1 protein and promotes breast cancer cell invasiveness.
Twist1 can be phosphorylated in vitro at Serin 68 by MAPKs (p38MAPKs, JNKs, ERK1/2)
This phosphorylation is required for Twist1 protein stability.
pSer 68 stabilizes Twist1 by protecting Twist1 from ubiquitination
Ser 68 phosphorylation is required for Twist1- promoted EMT and breast cancer cell invasion

JNK*|​Y185_pho|​T183_pho@Cytoplasm

References
a_re1316( Apoptosis  map ):
PMID:12624093
in mouse embryonic cells, with targeted disruption of either MAP2K4 or MAP2K7, the phosphorylation pattern of JNK reveals sequential phosphorylation by these MAP2Ks
a_re16( Apoptosis  map ):
PMID:15525785 GSK3B mediated phosphorylation of Bax S163
in HEK293 human cells
in rat cerebellar granule neurons
PMID:16709574 JNK- and p38- dependent phosphrylation of BAX, most probably on T167
in HepG2 human hepatoma cell line
in LLC-PK1 porcine kidney cell line
a_re23( Apoptosis  map ):
PMID:15071501
in COS cells, in HCT116 cells, phosphorylation of SFN and YWHAZ by JNK blocks their interaction with BAX
in vitro recombinant MKK7-JNK can directly phosphorylate YWHAZ
putative JNK phosphorylation sites conserved in YWHAB, YWHAE, YWHAZ, and SFN, but not in YWHAG, YWHAH nor YWHAQ
a_re432( Apoptosis  map ):
PMID:12591950
in vitro, phosphorylation of BimL by JNK, mutant Bim used for identification of phospho-sites
in 293T upon UV radiations
a_re1143( Apoptosis  map ):
logical:re1143_s3865_re1141=FALSE
logical:re1143_s3866_re1142=FALSE
PMID:16469705
a_re1317( Apoptosis  map ):
PMID:11064451
DUSP1
PMID:11359773
DUSP16
a_re1409( Apoptosis  map ):
PMID:9115213
S70 phosphorylation of BCL2 necessary for its antiapoptotic function
in NSF/N1.H7 mouse leukemia cells BCL2 mutants transfection) in response to IL-3, etoposide, or bryostatin-1, a PKC activator
PMID:9738012
suggest that PRKCA is the main PRKC BCL2 kinase in HL60 human acute myeloid leukemia cell line
PMID:10677502
ERK1/2 is a BCL2 S70 kinase in NSF/N1.H7 cells stimulated with IL-3
in vitro direct phosphorylation
PMID:11323415
JNK is a BCL2 S70 kinase in NSF/N1.H7 cells upon IL-3 withdrawal

JNK*@Cytoplasm

References
a_re1312:( Apoptosis  map ) reactionType:is.a
a_re1315( Apoptosis  map ):
PMID:12624093
in mouse embryonic cells, with targeted disruption of either MAP2K4 or MAP2K7, the phosphorylation pattern of JNK reveals sequential phosphorylation by these MAP2Ks

JNK*|​Y185_pho@Cytoplasm

References
a_re1315( Apoptosis  map ):
PMID:12624093
in mouse embryonic cells, with targeted disruption of either MAP2K4 or MAP2K7, the phosphorylation pattern of JNK reveals sequential phosphorylation by these MAP2Ks
a_re1317( Apoptosis  map ):
PMID:11064451
DUSP1
PMID:11359773
DUSP16

JNK*|​Y185_pho|​T183_pho@Nucleus

References
a_re1494( Apoptosis  map ):
PMID:16818236
upon UVA irradiation (no DSB), phosphorylation of H2AX S139 by JNK
effect of Y142 phosphorylation not assessed
PMID:19234442
interaction between JNK1 and H2AX Y142_pho dependent on FE65 (proposed FE65 scaffolding JNK to Y142_pho)
they propose H2AX Y142 phosphorylation as a switch toward apoptosis.
Even if not fully documented, the information from these 2 papers is merged into this representation where doubly phosphorylated H2AX cooperated with CAD for DNA fragmentation

JNK*|​pho|​active@default

References
d_re59:( DNA repair  map ) PMID:19788416

JNK*|​pho|​pho@Cytoplasm

References
s_mpk1_re156( Survival  map ):
MEK4 and MEK7 can activate all JNK isoforms (by phosphorylation).
PMID:11274345
s_mpk1_re169( Survival  map ):
JNK could phosphorylate NFAT4 and NFAT2 inhibiting their nuclear translocation.
s_mpk1_re183:( Survival  map ) Nuclear shuttling of activated JNK is assumed similarly to ERK.
s_mpk1_re188( Survival  map ):
P38 is able to suppress RAS-dependent JNK activation (probably through PRAK and MK2).
PMID:10978313
s_s_mpk1_re169( Survival  map ):

JNK*|​pho|​pho@Nucleus

References
s_mpk1_re183:( Survival  map ) Nuclear shuttling of activated JNK is assumed similarly to ERK.
s_mpk1_re91( Survival  map ):
The rapid and efficient phosphorylation of Elk1 by ERKs is enabled by a direct interaction between the two proteins.
ELK1 is a nuclear P38 target.
ELK1 is a nuclear JNK target.
PMID:16393692 PMID:20506250 PMID:11274345
s_mpk1_re176( Survival  map ):
ATF2 is a nuclear P38 target.
ATF2 is a nuclear JNK target.
PMID:20506250 PMID:11274345
s_mpk1_re178( Survival  map ):
JNKs are the dominant kinases responsible for stress- and TNF-activated C-JUN phosphorylation.
PMID:11274345
s_mpk1_re180( Survival  map ):
MKP-1 (DUSP1) preferentially inactivates JNK and P38.
PMID:19436832
s_mpk1_re261( Survival  map ):
JNK phosphorylates MST1 at serine 82 which leads to the enhancement of MST1 activation. The activation of MST1 phosphorylates FOXO3 at serine 207 and promotes cell death.
PMID:20028971


Modifications:
In compartment: Cytoplasm
  1. JNK*@Cytoplasm map

  2. JNK*|​Y185_pho@Cytoplasm map
  3. JNK*|​pho|​pho@Cytoplasm map
  4. JNK*|​Y185_pho|​T183_pho@Cytoplasm map

In compartment: Nucleus

  1. JNK*@Nucleus map

  2. JNK*|​pho|​pho@Nucleus map
  3. JNK*|​Y185_pho|​T183_pho@Nucleus map

In compartment: default

  1. JNK*@default map

  2. JNK*|​pho|​active@default map

Participates in complexes:
In compartment: Nucleus

  1. DUSP1:​JNK*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. JNK1*@Cytoplasm map map JNK*@Cytoplasm map

  2. JNK2*@Cytoplasm map map JNK*@Cytoplasm map
  3. JNK3*@Cytoplasm map map JNK*@Cytoplasm map
  4. JNK*@Cytoplasm map map JNK*|​Y185_pho@Cytoplasm map
  5. JNK*|​Y185_pho@Cytoplasm map map JNK*|​Y185_pho|​T183_pho@Cytoplasm map
  6. JNK*|​Y185_pho|​T183_pho@Cytoplasm map map JNK*|​Y185_pho@Cytoplasm map
  7. JNK*|​Y185_pho|​T183_pho@Cytoplasm map map JNK*|​Y185_pho|​T183_pho@Nucleus map
  8. JNK*|​Y185_pho@Cytoplasm map map JNK*@Cytoplasm map
  9. JNK*@default map map JNK*|​pho|​active@default map
  10. JNK*@Nucleus map map JNK1*@Nucleus map
  11. JNK*@Nucleus map map JNK2*@Nucleus map
  12. JNK*@Nucleus map map JNK3*@Nucleus map
  13. JNK*@Nucleus map map JNK pathway@Cytoplasm map
  14. JNK*@Cytoplasm map map JNK*|​pho|​pho@Cytoplasm map
  15. DUSP1@Nucleus map + JNK*|​pho|​pho@Nucleus map map DUSP1:​JNK*@Nucleus map
  16. JNK*|​pho|​pho@Cytoplasm map map JNK*|​pho|​pho@Nucleus map
  17. JNK*|​pho|​pho@Cytoplasm map map JNK*@Cytoplasm map
  18. ASK1*@Cytoplasm map map JNK*@Cytoplasm map
  19. JNK*@Cytoplasm map map Apoptosis@Mitochondria map
  20. JNK*@Cytoplasm map map MAPK pathway@Cytoplasm map

As Catalyser:

  1. ITCH@Cytoplasm map map ITCH|​pho@Cytoplasm map

  2. BCL2@Mitochondrial outer membrane map map BCL2|​pho@Mitochondrial outer membrane map
  3. H2AFX|​Y142_pho@Nucleus map map H2AFX|​S139_pho|​Y142_pho@Nucleus map
  4. BAX@Cytoplasm map map BAX|​S163_pho|​T167_pho@Cytoplasm map
  5. 14-3-3*@Cytoplasm map map 14-3-3*|​pho@Cytoplasm map
  6. BCL2L11:​DYNLL1@Cytoplasm map map BCL2L11|​S58_pho|​T56_pho|​S44_pho:​DYNLL1@Cytoplasm map
  7. CTBP*@Nucleus map map CTBP*|​S422_pho@Nucleus map
  8. BMF:​DYNLL2@Cytoplasm map map BMF|​pho:​DYNLL2@Cytoplasm map
  9. CTBP*@default map map CTBP*|​pho@default map
  10. TWIST1@Nucleus map map TWIST1|​S68_pho@Nucleus map
  11. NFAT*@Cytoplasm map map NFAT*|​pho@Cytoplasm map
  12. ATF2@Nucleus map map ATF2|​pho@Nucleus map
  13. JUN@Nucleus map map JUN|​pho@Nucleus map
  14. MST1@Nucleus map map MST1|​pho@Nucleus map
  15. ELK1@Nucleus map map ELK1|​pho@Nucleus map
  16. (NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map map (NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map

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