JNK pathway

Phenotype JNK pathway map
JNK pathway@Cytoplasm

References
e_re762( EMT  map ):
The association between the active GTP-bound form of CDC42 and the PBD domain of PAK1,2,3,4 promotes PAK1,2,3,4 autophosphorylation
PMID:16204230
PMID:9744077
PMID:10461188
PMID:11950587
All 4 kinases PAK1,2,3,4 are capable of promoting JNK signaling activation that leads to cytoskeletal rearrangement and cell motility.
e_re766( EMT  map ):
Rac1 activates JNK pathway vai PAK-independent mechanisms involving binding and stimulation of MAP3K (MAP3K10 and MAP3K11)
PMID:8910292
MLK3 overexpression is sufficient to activate JNK po- tently without affecting the phosphorylating activity of MAPK or p38
MLK3 binds the GTP-binding proteins Cdc42 and Rac1 in vivo and that MLK3 mediates activation of MEKK-SEK-JNK kinase cascade by Rac1 and Cdc42
PMID:9427749
MLK2 (MAP3K10) and MLK3 (MAP3K11) interact with the activated (GTP-bound) forms of Rac and Cdc42, with a slight preference for Rac.
When expressed in fibroblasts, MLK2 co-localizes with active, dually phosphorylated JNK to punctate structures along microtubules.
MLK2 and MLK3 interact with members of the KIF3 family of kinesin superfamily motor proteins and with KAP3A, the putative targeting component of KIF3 motor complex
PMID:11713255
Rac1 coordinately activates p70S6K and JNK via MLK3 activation
e_re870( EMT  map ):
PMID:17161586
CDC42 can activate JNL pathway aslo by binding and stimulation of MAP3K11 (MLK3).


Modifications:
In compartment: Cytoplasm
  1. JNK pathway@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. JNK*@Nucleus map map JNK pathway@Cytoplasm map

    2. MAP3K7@Cytoplasm map map JNK pathway@Cytoplasm map
    3. PAK*|​pho|​active@Cytoplasm map map JNK pathway@Cytoplasm map
    4. MAP3K7_10_11*@Cytoplasm map map JNK pathway@Cytoplasm map
    5. PAK4@Cytoplasm map map JNK pathway@Cytoplasm map
    6. MAP3K11@Cytoplasm map map JNK pathway@Cytoplasm map
    7. JNK pathway@Cytoplasm map map JUN|​S63_pho|​S73_pho|​active@Nucleus map
    8. s_s_wnc1_s945 map JNK pathway@Cytoplasm map
    9. JNK pathway@Cytoplasm map map JUN@Nucleus map
    10. JNK pathway@Cytoplasm map map JUND@Nucleus map
    11. JNK pathway@Cytoplasm map map JUNB@Nucleus map

    As Catalyser:

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