ITGB3

RNA ITGB3 map

Identifiers
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
GP3A
HUGO:ITGB3 HGNC:6156 ENTREZ:3690 UNIPROT:P05106 GENECARDS:ITGB3 REACTOME:57601 KEGG:3690 ATLASONC:GC_ITGB3 WIKI:ITGB3

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map

rITGB3@Nucleus

References
e_re177( EMT  map ):
PMID:10048576
The gene expressions of MMP-1, MMP-3, and MMP-9 and gelatinolytic activity of MMP-9 were significantly increased in high ETS-1 expression cells.
Low ETS-1 expression cells could not spread on a vitronectin substratum, and the phosphorylation of focal adhesion kinase was markedly impaired because of the reduced expression of integrin b3
PMID:7512751
PMID:7528107
Integrin aVb3 plays an important role in angiogenesis. Bblocking of the binding of endothelial integrin aVb3 inhibits angiogenesis and forces neovascular ECs into apoptosis (Brooks et al., 1994a,b).
PMID:24376839
PTP4A3 is implicated in cell adhesion and the regulation of focal adhesion components including integrin beta-1, Src, paxillin and p130Cas
Similarly, PTP4A3 promotes cell invasion by increasing MMP2 activity and decreasing the expression of the MMP inhibitor, TIMP2.
PTP4A3 is also involved in EMT: PTP4A3 overexpression in colorectal carcinoma cells downregulates epithelial markers (E-cadherin, plakoglobin, and integrin beta-3) and upregulates expression of mesenchymal markers (fibronectin and snail1).
PMID:23691193
Src-mediated phosphorylation of PTP4A3 Is required for Rho activation, motility and invasion promoted by PTP4A3.


Modifications:
In compartment: Nucleus
  1. rITGB3@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gITGB3@Nucleus map map rITGB3@Nucleus map

    2. rITGB3@Nucleus map map ITGB3@Cytoplasm map

    As Catalyser:

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