ITGB1

Protein ITGB1 map

Identifiers
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
HUGO:ITGB1 HGNC:6153 ENTREZ:3688 UNIPROT:P05556 GENECARDS:ITGB1 REACTOME:57597 KEGG:3688 ATLASONC:GC_ITGB1 WIKI:ITGB1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map
 EMT  map  / ECM  map
 EMT  map  / CELL_CELL_ADHESIONS  map

References
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
PMID:19487819
During gastrulation, type 1 EMT is associated with de novo expression of a5b1, which is a receptor for fibronectin.
Type 2 EMT in experimental kidney fibrosis is associated with increased a5 integrin expression.
PMID:9003039
L1 also interacts heterophilically with laminin in the context of mouse small cerebellar neurons
Integrins (b1, a3, a6) could be shown to bind to laminin by a b1-dependent adhesion mechanism.
L1 was demonstrated to bind in a concentration-dependent and saturating manner to laminin.
Furthermore, antibodies to the Ig-like domains of L1 and b1 integrin inhibited partially cell adhesion to laminin.

ITGB1@Cytoplasm

References
e_re520( EMT  map ):
PMID:11309411
Claudin-11 forms a complex with TSPAN3 and ITGB1.
This interaction potentially regulates proliferation and migration of oligodendrocytes.
e_re521( EMT  map ):
PMID:15471980
PMID:17498653
The phosphorylation of caveolin-1 served to recruit C-terminal Src-like kinase (Csk) to the integrin/caveolin-1 complex.
This recruitment results in additional regulation of SFK activity and induction of myosin light chain (MLC) phosphorylation.
Key components of this pathway were recruited to caveolar microdomains and dependent on the presence of the caveolin-1 protein.
PMID:21051664
p190RhoGAP links integrins and caveolin-1 (and thus caveolae) to RhoA in a mechanotransduction cascade
e_re978( EMT  map ):
Autophosphorylation of PTK2:
PMID:7529872
PMID:19339212
PMID:7657702
PMID:16919435
FAK (PTK2) is first recruited to sites of integrin clustering via interactions wiith integrin-associated proteins such as talin, paxillin.
FAK binds to the cytoplasmic domain of b1 integrin via Paxillin (PXN) and Talin (TLN)
Binding to aVb3 or a5b1 integrins induces PTK2 (FAK1) autophosphorylation at Y397.
PMID:10545505
FAK associates with paxillin, vinculin, and p130cas (BCAR1) in the focal adhesion complex
Integrins control motile strategy through a Rho-cofilin pathway.
beta1 integrins promote random migration, whereas beta3 integrins promote persistent migration in the same epithelial cell background.
Adhesion to fibronectin by aVb3 supports actin cytoskeletal reorganization via cofilin, resulting in a single broad lamellipod with static cell-matrix adhesions at the leading edge.
Adhesion by a5b1 instead leads to the phosphorylation and thus inactivation of cofilin, and these cells fail to polarize their cytoskeleton but extend thin protrusions containing highly dynamic cell-matrix adhesions in multiple directions.
The activity of the small GTPase RhoA is particularly high in cells adhering by a5b1, and inhibition of Rho signaling causes a switch from a beta1 to a beta3-associated mode of migration, whereas increased Rho activity has the opposite effect.
Alterations in integrin expression profiles thus allow cells to modulate several critical aspects of the motile machinery through Rho GTPases.


Modifications:
In compartment: Cytoplasm
  1. ITGB1@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. ITGA1:​ITGB1@Cytoplasm map

  2. ITGA1:​ITGB1@Cytoplasm map
  3. ITGA2:​ITGB1@Cytoplasm map
  4. ITGA2:​ITGB1@Cytoplasm map
  5. ITGA3:​ITGB1@Cytoplasm map
  6. ITGA3:​ITGB1@Cytoplasm map
  7. ITGA4:​ITGB1@Cytoplasm map
  8. ITGA4:​ITGB1@Cytoplasm map
  9. ITGA5:​ITGB1@Cytoplasm map
  10. ITGA5:​ITGB1@Cytoplasm map
  11. ITGA6:​ITGB1@Cytoplasm map
  12. ITGA6:​ITGB1@Cytoplasm map
  13. ITGA7:​ITGB1@Cytoplasm map
  14. ITGA7:​ITGB1@Cytoplasm map
  15. ITGA8:​ITGB1@Cytoplasm map
  16. ITGA8:​ITGB1@Cytoplasm map
  17. ITGA9:​ITGB1@Cytoplasm map
  18. ITGA9:​ITGB1@Cytoplasm map
  19. ITGAV:​ITGB1@Cytoplasm map
  20. ITGAV:​ITGB1@Cytoplasm map
  21. ITGA10:​ITGB1@Cytoplasm map
  22. ITGA10:​ITGB1@Cytoplasm map
  23. ITGA11:​ITGB1@Cytoplasm map
  24. ITGA11:​ITGB1@Cytoplasm map
  25. Caveolin1*:​ITGB1@Cytoplasm map
  26. Claudin11*:​ITGB1:​TSPAN3@Cytoplasm map

In compartment: Extracellular space

  1. (ITGA5:​ITGB1)|​active@Extracellular space map

Participates in reactions:
As Reactant or Product:

  1. Galectin 3 partners*@Extracellular space map map ITGA3:​ITGB1@Cytoplasm map

  2. Laminin 1 partners*@Extracellular space map map ITGA3:​ITGB1@Cytoplasm map
  3. Collagen2 partners*@Extracellular space map map ITGA10:​ITGB1@Cytoplasm map
  4. Collagen2 partners*@Extracellular space map map ITGA2:​ITGB1@Cytoplasm map
  5. Fibronectin partners*@Extracellular space map map ITGA10:​ITGB1@Cytoplasm map
  6. Fibronectin partners*@Extracellular space map map ITGA2:​ITGB1@Cytoplasm map
  7. Talin partners*@Cytoplasm map map ITGB1@Cytoplasm map
  8. Talin partners*@Cytoplasm map map ITGAV:​ITGB1@Cytoplasm map
  9. Talin partners*@Cytoplasm map map ITGA5:​ITGB1@Cytoplasm map
  10. Talin partners*@Cytoplasm map map ITGA2:​ITGB1@Cytoplasm map
  11. Talin partners*@Cytoplasm map map ITGA1:​ITGB1@Cytoplasm map
  12. Talin partners*@Cytoplasm map map ITGA10:​ITGB1@Cytoplasm map
  13. rITGB1@Nucleus map map ITGB1@Cytoplasm map
  14. ITGAV@Cytoplasm map + ITGB1@Cytoplasm map map ITGAV:​ITGB1@Cytoplasm map
  15. ITGAV:​ITGB1@Cytoplasm map map ITGAV:​ITGB1@Cytoplasm map
  16. ITGA3@Cytoplasm map + ITGB1@Cytoplasm map map ITGA3:​ITGB1@Cytoplasm map
  17. ITGA3:​ITGB1@Cytoplasm map map ITGA3:​ITGB1@Cytoplasm map
  18. ITGA6@Cytoplasm map + ITGB1@Cytoplasm map map ITGA6:​ITGB1@Cytoplasm map
  19. ITGA6:​ITGB1@Cytoplasm map map ITGA6:​ITGB1@Cytoplasm map
  20. ITGA7@Cytoplasm map + ITGB1@Cytoplasm map map ITGA7:​ITGB1@Cytoplasm map
  21. ITGA7:​ITGB1@Cytoplasm map map ITGA7:​ITGB1@Cytoplasm map
  22. ITGA2@Cytoplasm map + ITGB1@Cytoplasm map map ITGA2:​ITGB1@Cytoplasm map
  23. ITGA2:​ITGB1@Cytoplasm map map ITGA2:​ITGB1@Cytoplasm map
  24. ITGA1@Cytoplasm map + ITGB1@Cytoplasm map map ITGA1:​ITGB1@Cytoplasm map
  25. ITGA1:​ITGB1@Cytoplasm map map ITGA1:​ITGB1@Cytoplasm map
  26. ITGA11@Cytoplasm map + ITGB1@Cytoplasm map map ITGA11:​ITGB1@Cytoplasm map
  27. ITGA11:​ITGB1@Cytoplasm map map ITGA11:​ITGB1@Cytoplasm map
  28. ITGA10@Cytoplasm map + ITGB1@Cytoplasm map map ITGA10:​ITGB1@Cytoplasm map
  29. ITGA10:​ITGB1@Cytoplasm map map ITGA10:​ITGB1@Cytoplasm map
  30. ITGA8@Cytoplasm map + ITGB1@Cytoplasm map map ITGA8:​ITGB1@Cytoplasm map
  31. ITGA8:​ITGB1@Cytoplasm map map ITGA8:​ITGB1@Cytoplasm map
  32. ITGA4@Cytoplasm map + ITGB1@Cytoplasm map map ITGA4:​ITGB1@Cytoplasm map
  33. ITGA4:​ITGB1@Cytoplasm map map ITGA4:​ITGB1@Cytoplasm map
  34. ITGA5@Cytoplasm map + ITGB1@Cytoplasm map map ITGA5:​ITGB1@Cytoplasm map
  35. ITGA5:​ITGB1@Cytoplasm map map ITGA5:​ITGB1@Cytoplasm map
  36. ITGA9@Cytoplasm map + ITGB1@Cytoplasm map map ITGA9:​ITGB1@Cytoplasm map
  37. ITGA9:​ITGB1@Cytoplasm map map ITGA9:​ITGB1@Cytoplasm map
  38. TSPAN3@Cytoplasm map + Claudin11*@Cytoplasm map + ITGB1@Cytoplasm map map Claudin11*:​ITGB1:​TSPAN3@Cytoplasm map
  39. Caveolin1*@Cytoplasm map + ITGB1@Cytoplasm map map Caveolin1*:​ITGB1@Cytoplasm map
  40. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*@Extracellular space map map ITGA8:​ITGB1@Cytoplasm map
  41. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*@Extracellular space map map ITGAV:​ITGB1@Cytoplasm map
  42. a1b1*_a2b1*@Extracellular space map map ITGA1:​ITGB1@Cytoplasm map
  43. a1b1*_a2b1*@Extracellular space map map ITGA2:​ITGB1@Cytoplasm map
  44. a2b1*_a3b1*@Extracellular space map map ITGA2:​ITGB1@Cytoplasm map
  45. a2b1*_a3b1*@Extracellular space map map ITGA3:​ITGB1@Cytoplasm map
  46. a5b1*_aVb3*@Extracellular space map map ITGA5:​ITGB1@Cytoplasm map
  47. a6b1*_a6b4*@Extracellular space map map ITGA6:​ITGB1@Cytoplasm map
  48. Fibronectin*:​a5b1*_aVb3*@Extracellular space map map (ITGA5:​ITGB1)|​active@Extracellular space map

As Catalyser:

  1. CFL1@Cytoplasm map map CFL1|​pho@Cytoplasm map

  2. FAK1*|​emp@Cytoplasm map map FAK1*|​pho@Cytoplasm map

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