ITGA8:ITGB1

Complex ITGA8:ITGB1 map


Complex composition:

  1. ITGB1 map
  2. ITGA8 map




ITGA8:​ITGB1@Cytoplasm

Identifiers
NAME:ITGA8:ITGB1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map

References
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
PMID:21909923
Ligands for a8b1: Latent TGFb, tenascin, fibronectin, osteoponitin, vitronectin, nephronectin
e_re978( EMT  map ):
Autophosphorylation of PTK2:
PMID:7529872
PMID:19339212
PMID:7657702
PMID:16919435
FAK (PTK2) is first recruited to sites of integrin clustering via interactions wiith integrin-associated proteins such as talin, paxillin.
FAK binds to the cytoplasmic domain of b1 integrin via Paxillin (PXN) and Talin (TLN)
Binding to aVb3 or a5b1 integrins induces PTK2 (FAK1) autophosphorylation at Y397.
PMID:10545505
FAK associates with paxillin, vinculin, and p130cas (BCAR1) in the focal adhesion complex
Integrins control motile strategy through a Rho-cofilin pathway.
beta1 integrins promote random migration, whereas beta3 integrins promote persistent migration in the same epithelial cell background.
Adhesion to fibronectin by aVb3 supports actin cytoskeletal reorganization via cofilin, resulting in a single broad lamellipod with static cell-matrix adhesions at the leading edge.
Adhesion by a5b1 instead leads to the phosphorylation and thus inactivation of cofilin, and these cells fail to polarize their cytoskeleton but extend thin protrusions containing highly dynamic cell-matrix adhesions in multiple directions.
The activity of the small GTPase RhoA is particularly high in cells adhering by a5b1, and inhibition of Rho signaling causes a switch from a beta1 to a beta3-associated mode of migration, whereas increased Rho activity has the opposite effect.
Alterations in integrin expression profiles thus allow cells to modulate several critical aspects of the motile machinery through Rho GTPases.

Confidence
REF=4 FUNC=0

ITGA8:​ITGB1@Cytoplasm

Identifiers
NAME:ITGA8:ITGB1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map

References
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
PMID:21909923
Ligands for a8b1: Latent TGFb, tenascin, fibronectin, osteoponitin, vitronectin, nephronectin

Confidence
REF=0 FUNC=5


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. ITGA8:​ITGB1@Cytoplasm map

  2. ITGA8:​ITGB1@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. ITGA8@Cytoplasm map + ITGB1@Cytoplasm map map ITGA8:​ITGB1@Cytoplasm map

  2. ITGA8:​ITGB1@Cytoplasm map map ITGA8:​ITGB1@Cytoplasm map
  3. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*@Extracellular space map map ITGA8:​ITGB1@Cytoplasm map

As Catalyser:

  1. FAK1*|​emp@Cytoplasm map map FAK1*|​pho@Cytoplasm map

Leave a Reply