ITGA5

Protein ITGA5 map

Identifiers
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
HUGO:ITGA5 HGNC:6141 ENTREZ:3678 UNIPROT:P08648 GENECARDS:ITGA5 REACTOME:57569 KEGG:3678 ATLASONC:GC_ITGA5 WIKI:ITGA5

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map
 EMT  map  / ECM  map

References
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
PMID:19487819
During gastrulation, type 1 EMT is associated with de novo expression of a5b1, which is a receptor for fibronectin.
Type 2 EMT in experimental kidney fibrosis is associated with increased a5 integrin expression.

ITGA5@Cytoplasm

References
e_re963( EMT  map ):
PMID:11121431
PMID:15157156
PMID:15229651
Nischarin binds preferentially to the cytoplasmic tail of ITGA5 subunit ti inhibit cell migration.
Nischarin is not found in focal adhesion sites.
Once integrins enter into adhesion sites, Nischarin is released, allowing it to bind to the activated PAK1 in order to inactive PAK1..
This binding is enhaced by active Rac1.
The ability of Nischarin to inhibit PAK1 is related to its ability to inhibit cell motility.


Modifications:
In compartment: Cytoplasm
  1. ITGA5@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. ITGA5:​ITGB1@Cytoplasm map

  2. ITGA5:​ITGB1@Cytoplasm map
  3. ITGA5:​NISCH@Cytoplasm map

In compartment: Extracellular space

  1. (ITGA5:​ITGB1)|​active@Extracellular space map

Participates in reactions:
As Reactant or Product:

  1. rITGA5@Nucleus map map ITGA5@Cytoplasm map

  2. Talin partners*@Cytoplasm map map ITGA5:​ITGB1@Cytoplasm map
  3. ITGA5@Cytoplasm map + ITGB1@Cytoplasm map map ITGA5:​ITGB1@Cytoplasm map
  4. ITGA5:​ITGB1@Cytoplasm map map ITGA5:​ITGB1@Cytoplasm map
  5. a5b1*_aVb3*@Extracellular space map map ITGA5:​ITGB1@Cytoplasm map
  6. Fibronectin*:​a5b1*_aVb3*@Extracellular space map map (ITGA5:​ITGB1)|​active@Extracellular space map
  7. ITGA5@Cytoplasm map + NISCH@Nucleus map map ITGA5:​NISCH@Cytoplasm map

As Catalyser:

  1. CFL1@Cytoplasm map map CFL1|​pho@Cytoplasm map

  2. FAK1*|​emp@Cytoplasm map map FAK1*|​pho@Cytoplasm map

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