Interstrand crosslinking agents*

Drug Interstrand crosslinking agents* map
Interstrand crosslinking agents*@Nucleus

Identifiers
Cisplatin
CAS:15663-27-1, PUBCHEM:301178, KEGGDRUG:D00275
Mitomicyn C
CAS:50-07-7, PUBCHEM:5746, KEGGDRUG:D00208
Oxaliplatin
CAS:61825-94-3, PUBCHEM:5310940, KEGGDRUG:D01790
Carboplatin
Satraplatin
Picoplatin
Cyclophosphamide
Melphalan
Chlorambucil
Ifosfamide
Psoralen
Pyrrolobenzodiazepine

Maps_Modules
 DNA repair  map  / HR  map
 DNA repair  map  / TLS  map
 DNA repair  map  / FANCONI  map
 DNA repair  map  / NER  map

References
PMID:22258607, PMID:22918414
Cisplatin
PMID:21115814, PMID:23444773
Oxaliplatin
PMID:22614106
Mitomycin C
PMID:23444773
For actIvation of TLS by interstrand crosslinking agents
PMID:20015866, PMID:15155842, PMID:22122464, PMID:23106263, PMID:21666254, PMID:20658647
For activation of HR, Fanconi and NER by interstrand crosslinking agents
PMID:21701511
d_re515( DNA repair  map ):
http://dnatraffic.ibb.waw.pl/classification/dna_damages
PMID:22258607, PMID:19267553, PMID:18256616
FOR HR activation by IR
PMID:20723763
For HR activation by UV
PMID:21885354, PMID:22987150, PMID:20206282, PMID:19398948, PMID:1575062
Interstrand crosslinking agents activate HR
Topoisomerate inhibitors bloch double strand DNA repair by HR, C_NHEJ and Fanconi pathways
PMID:23259582
For HR
PMID:22123462, PMID:20693240
FOR Fanconi
PMID:21414716, PMID:23157317
For activation by Dbait
PMID:22068457, PMID:22815765, PMID:22042585, PMID:19621083
d_re516( DNA repair  map ):
For actovation of TLS by UV
PMID:22521143
d_re517( DNA repair  map ):
UV light causes bulky adducts damage in DNA that repared by NER pathway
For activation of NER by UV
PMID:22743272, PMID:22822215, PMID:22492724, PMID:22373527
Interstrand crosslinking agents induce NER
ROS activate NER for repating intrastrand crosslink
PMID:22581771
ROS activate NER for bulky adducts
PMID:18189366
d_re519( DNA repair  map ):
PMID:22743272, PMID:22822215, PMID:22492724, NER:22373527
Transcription-dependent NER and damage by UV
PMID:20045328, PMID:14599741
d_re520( DNA repair  map ):
PMID:17145857
Fanconi is activated by interstrand crosslinking agents
PMID:23444773, PMID:21948210, PMID:21701511


Modifications:
In compartment: Nucleus
  1. Interstrand crosslinking agents*@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

      As Catalyser:

      1. gIntact_DNA*@Nucleus map map gHR_DNA_st1*@Nucleus map

      2. gIntact_DNA*@Nucleus map map gTLS_DNA_st1*@Nucleus map
      3. gIntact_DNA*@Nucleus map map gGG-NER_DNA_st1*@Nucleus map
      4. gIntact_DNA*@Nucleus map map gTC-NER_DNA_st1*@Nucleus map
      5. gIntact_DNA*@Nucleus map map gFanconi_DNA_st1*@Nucleus map

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