Integrin A8B1_AVB1_AVB5_AVB6_AVB8*

Protein Integrin A8B1_AVB1_AVB5_AVB6_AVB8* map

Identifiers
Integrin A8B1_AVB1_AVB5_AVB6_AVB8*
NAME:a8b1*
ITGA8/ITGB1
NAME:aVb1*
ITGAV/ITGB1
NAME:aVb5*
ITGAV/ITGB5
NAME:aVb6*
ITGAV/ITGB6
NAME:aVb8*
ITGAV/ITGB8

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

Integrin A8B1_AVB1_AVB5_AVB6_AVB8*@Extracellular space

References
e_re197( EMT  map ):
PMID:21900405
LAP contains an integrin-binding site called RBD
Several RBD-binding integrins are able to activate latnet TGFB complex through binding this site.
PMID:21909923
The previously mentionned integrins are: a8b1, aVb1, aVb5, aVb6, aVb8.
In the complex Ingergin-large latent TGFB complex, I picked aVb6 as example. But a8b1, aVb1, aVb5, and aVb8 can active TGFB with the same mechanism.
MMP13 activates TGFB by cleavage of LAP
Plasmin activates TGFB by cleavage of LAP
MMP9 activates TGFB by cleavage of LAP
Integrin aVb6 activates the ECM-bound latent TGFB1 and TGFB3 by traction, without participation of MMPs, so no hydrolyse or clevage
Integrin aVb8 and MMP14 (so-called MT1-MMP) cooperate to activate the ECM-bound latent TGFB1 and TGFB3:
-Integrin aVb8 binds LAP from the large latent complex
-MMP14 then is recruited to cleave LAP


Modifications:
In compartment: Extracellular space
  1. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*@Extracellular space map

Participates in complexes:
In compartment: Extracellular space

  1. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2@Extracellular space map

  2. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map
  3. Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map

Participates in reactions:
As Reactant or Product:

  1. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*@Extracellular space map + LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map

  2. Actin cytoskeletal*@Cytoplasm map + Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map
  3. Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2@Extracellular space map + TGFB1|​hm2|​active@Extracellular space map
  4. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*@Extracellular space map map ITGA8:​ITGB1@Cytoplasm map
  5. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*@Extracellular space map map ITGAV:​ITGB1@Cytoplasm map
  6. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*@Extracellular space map map ITGAV:​ITGB5@Cytoplasm map
  7. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*@Extracellular space map map ITGAV:​ITGB6@Cytoplasm map
  8. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*@Extracellular space map map ITGAV:​ITGB8@Cytoplasm map

As Catalyser:

    48 thoughts on “Integrin A8B1_AVB1_AVB5_AVB6_AVB8*

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