IMP*

Protein IMP* map

Identifiers
BRCA1 associated protein
HUGO:BRAP HGNC:1099 ENTREZ:8315 UNIPROT:Q7Z569 GENECARDS:BRAP KEGG:8315 ATLASONC:GC_BRAP WIKI:BRAP

Maps_Modules
 Survival  map  / MAPK  map

References
IMP (BRAP) is a RasGTP-interacting protein. It is constitutively bound to KSR1 blocking the enhancement of ERK activation (KSR1 is kept in an inactivated state) maybe recruiting KSR1 to microdomains inaccessible to activators of its function.
This could be a mechanism to limit the engagement of ERK cascade in the absence of Ras activation.
PMID:14724641

IMP*@Cytoplasm

References
s_mpk1_re35( Survival  map ):
RasGTP interacts with IMP cleaving it from KSR1. In this way KSR1 can play its role of scaffolding protein for ERK cascade.
Ras activation causes the cleavage of 14-3-3 from KSR1 (not modelled) exposing the membrane-targeting C1 domain as well as the docking site for ERK1/2.
PMID:14724641 PMID:17496910


Modifications:
In compartment: Cytoplasm
  1. IMP*@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. IMP*:​KSR1:​MEK*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. IMP*:​KSR1:​MEK*@Cytoplasm map map IMP*@Cytoplasm map + KSR1:​MEK*@Cytoplasm map

As Catalyser:

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