IGF family*:IGF1R

Complex IGF family*:IGF1R map


Complex composition:

  1. IGF1R map
  2. IGF family* map




IGF family*:​IGF1R|​hm2@Cytoplasm

Identifiers
NAME:IGF family*:IGF1R

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
PMID:12175651
PMID:10826997
PMID:12767520
PMID:19030972
PMID:16931767
PMID:21540285
PMID:12444011

Confidence
REF=1 FUNC=5

IGF family*:​IGF1R|​Y_pho|​hm2@Cytoplasm

Identifiers
NAME:IGF family*:IGF1R

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
PMID:12175651
PMID:10826997
PMID:12767520
PMID:19030972
PMID:16931767
PMID:21540285
PMID:12444011
e_re1618( EMT  map ):
IGFfamily exhibits anti-apoptotic activity.
Three IGF1R-induced anti-apoptotic pathways:
1. IRS1-mediated pathway causing activation of PI3K and AKT(PKB) leading to BAD phosphorylation.
Unphosphorylated BAD, by binding to BCLXL and BCL2, neutralizes the protective effect of these 2 later proteins and promotes cell death.
Phosphorylated BAD is sequestered by 14-3-3 protein family and thus unable to bind BCL2 family hence can not promote cell death.
2. After autophosphorylation and thus activation, IGF1R binds and postively influence on 14-3-3 protein family, leading to activation and translocation of c-Raf1 to the mitochondria where it phosphorylates BAD.
3. IGF1R specifically phosphorylates and inhibits ASK1 (MAP3K5)

Confidence
REF=1 FUNC=5


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. IGF family*:​IGF1R|​hm2@Cytoplasm map

  2. IGF family*:​IGF1R|​Y_pho|​hm2@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. IGF1R@Cytoplasm map + IGF family*@Extracellular space map map IGF family*:​IGF1R|​hm2@Cytoplasm map

  2. IGF family*:​IGF1R|​hm2@Cytoplasm map map IGF family*:​IGF1R|​Y_pho|​hm2@Cytoplasm map
  3. IGF family*:​IGF1R|​Y_pho|​hm2@Cytoplasm map map 14-3-3*@Cytoplasm map

As Catalyser:

  1. SHC1_p66_p52*@Cytoplasm map map SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytoplasm map

  2. IRS1@Cytoplasm map map IRS1|​Y_pho|​active@Cytoplasm map
  3. MAP3K5@Cytoplasm map map MAP3K5|​pho@Cytoplasm map

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