inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
e_re1247( EMT ):
ID2 is target of HIF1 upon hypoxic conditions
TGFB induces ETS1 transcriptional expression.
TGFB represses ID2 and ID3 transcriptional expression (PMID:15121845 and PMID:15181457)
ID2 may regulate the function of Ets1 to modulate the transcription of ZEB1 and ZEB2 without alteration of the transcription of Ets1.
Ets1 may act as an inducer of ZEB1 in collaboration with E47 (TCF3)
In compartment: Nucleus
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As Reactant or Product: