ID*

Protein ID* map

Identifiers
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:15252039
ID is so-called Inhibitor of differentiation/DNA binding proteins
ID proteins is frequently deregulated in advanced human malignancies.
ID proteins can participate in blocking differentiation, increasing proliferation, tissue invasiveness, and angiogenesis.
PMID:17615296
Through constitutive association with bHLH E12/E47 proteins, Id proteins maintain epithelial phenotypes by repressing the function of E12/E47, which acts as a repressor of E-cadherin.
Down-regulation of ID1 by Smad2/3/ATF3 complex and of ID2 as well as ID3 by TGFB thus relieve this inhibition, permitting conversion of epithelial cells to cells with mesenchymal phenotypes
TGFB induces ETS1 transcriptional expression.
TGFB represses ID2 and ID3 transcriptional expression (PMID:15121845 and PMID:15181457)
ID2 may regulate the function of Ets1 to modulate the transcription of ZEB1 and ZEB2 without alteration of the transcription of Ets1.
Ets1 may act as an inducer of ZEB1 in collaboration with E47 (TCF3)

ID*@Nucleus

References
e_re1251( EMT  map ):
PMID:15252039
ID is so-called Inhibitor of differentiation/DNA binding proteins
ID proteins is frequently deregulated in advanced human malignancies.
ID proteins can participate in blocking differentiation, increasing proliferation, tissue invasiveness, and angiogenesis.
e_re1260( EMT  map ):
PMID:15121845
PMID:18832382
PMID:15181457
ID proteins can form complexes with TCF3 (E47), and inhibit the process of EMT.


Modifications:
In compartment: Nucleus
  1. ID*@Nucleus map

Participates in complexes:
In compartment: Nucleus

  1. E-protein*:​ID*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. ID*@Nucleus map map ID1@Nucleus map

  2. ID*@Nucleus map map ID2@Nucleus map
  3. ID*@Nucleus map map Angiogenesis@Nucleus map
  4. ID*@Nucleus map map Invasiveness@Cytoplasm map
  5. ID*@Nucleus map map ID3@Nucleus map
  6. E-protein*@Nucleus map + ID*@Nucleus map map E-protein*:​ID*@Nucleus map

As Catalyser:

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