Hypoxia

Phenotype Hypoxia map
Hypoxia@Cytoplasm

Identifiers
Hypoxia

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
e_re1240( EMT  map ):
PMID:22945800
Angiognesis is triggered by hypoxia and inflammation, conditions that are also known inducers of EMT
e_re1253( EMT  map ):
http://www.omicsonline.org/1948-5956/JCST-03-035.php
HIF-1 is the Commander of Gateways to Cancer
PMID:16887934
PMID:9159130
HIF-1B (ARNT) is constitutively expressed and its mRNA and protein are maintained at constant levels regardless of oxygen availability
PMID:9278421
HIF-1A protein has a short half-life (t1/2 = 5 min) and is highly regulated by oxygen
PMID:9746763
The transcription and synthesis of HIF-1B are constitutive and seem not to be affected by oxygen.
PMID:7539918
In normoxia, the HIF-1A proteins are rapidly degraded, resulting in essentially no detectable HIF-1A protein.
PMID:8943284
During hypoxia, HIF-1A becomes stabilized and translocates from the cytoplasm to the nucleus, where it dimerizes with HIF-1B and the HIF complex formed becomes transcriptionally active
PMID:1823643
The activated HIF complex then associates with HREs in the regulatory regions of target genes and binds the transcriptional coactivators to induce gene expression.
PMID:15451019
Tight regulation of the stability and subsequent transactivational function of HIF-1A is chiefly controlled by its post-translation modifications, such as hydroxylation, ubiquitination, acetylation, and phosphorylation
The modification of HIF-1A occurs within several domains.
PMID:10403805
PMID:11566883
PMID:12829734
In normoxia, hydroxylation of 2 proline residues and acetylation of a lysine residue in its ODDD promote interaction of HIF-1A with the von Hippel-Lindau (pVHL) ubiquitin E3 ligase complex (Srinivas et al., 1999; Masson et al., 2001).
PMID:12080085
pVHL complex tags HIF-1A with ubiquitin and thereby marks it for degradation by the 26S proteasome.
In addition, hydroxylation of an asparagine residue in the C-TAD inhibits the association of HIF-1A with CBP/p300 and thus inhibits its transcriptional activity (Lando et al., 2002a).


Modifications:
In compartment: Cytoplasm
  1. Hypoxia@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. Hypoxia@Cytoplasm map map ROS@Mitochondria map

    2. Hypoxia@Cytoplasm map map Angiogenesis@Nucleus map
    3. Hypoxia@Cytoplasm map map HIF_alpha_*@Cytoplasm map

    As Catalyser:

      Leave a Reply