HSP90*

Protein HSP90* map

Identifiers
heat shock protein 90kDa alpha (cytosolic), class A member 1
HUGO:HSP90AA1 HGNC:5253 ENTREZ:3320 UNIPROT:P07900 GENECARDS:HSP90AA1 REACTOME:56696 KEGG:3320 ATLASONC:GC_HSP90AA1 WIKI:HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 2
HUGO:HSP90AA2 HGNC:5256 ENTREZ:3324 UNIPROT:Q14568 GENECARDS:HSP90AA2 ATLASONC:GC_HSP90AA2 WIKI:HSP90AA2
heat shock protein 90kDa alpha (cytosolic), class B member
HUGO:HSPC2 GENECARDS:HSPC2 KEGG:3326 WIKI:HSPC2 HUGO:HSP90AB1 HGNC:5258 ENTREZ:3326 UNIPROT:P08238 GENECARDS:HSP90AB1 REACTOME:56698 KEGG:3326 ATLASONC:GC_HSP90AB1 WIKI:HSP90AB1
Heat shock protein 90 kDa alpha class A member 1
Heat shock protein 90 kDa alpha class A member 2
Heat shock protein 90 kDa alpha class B member 1
HUGO:HSP90AB1 HGNC:5258 ENTREZ:3326 UNIPROT:P08238 GENECARDS:HSP90AB1 REACTOME:56698 KEGG:3326 ATLASONC:GC_HSP90AB1 WIKI:HSP90AB1 HUGO:HSPC2 GENECARDS:HSPC2 KEGG:3326 WIKI:HSPC2
Heat shock protein 90 kDa beta member 1
HUGO:HSP90B1 HGNC:12028 ENTREZ:7184 UNIPROT:P14625 GENECARDS:HSP90B1 REACTOME:54332 KEGG:7184 ATLASONC:GC_HSP90B1 WIKI:HSP90B1

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 DNA repair  map  / HR  map
 DNA repair  map  / FANCONI  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 Cell cycle  map  / CYCLIND  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:22869732, PMID:17327415
PMID:19387550
PMID:19662498
PMID:18566586
PMID:10995457

HSP90*@Cytoplasm

References
a_re479:( Apoptosis  map ) reactionType:is.a
a_re386( Apoptosis  map ):
PMID:10973499
in vitro reconstitution of the E3-ligase activity, with VHL, elonginB/C, RBX1,CUL2
PMID:18985005
in COS monkey kidney cells and Caki-I human renal carcinoma cells, inhibition of VHL-mediated HIF1A ubiquitinylation and degradation by ectopically expressed constitutively active STAT3
a_re488:( Apoptosis  map ) PMID:10944114
a_re718:( Apoptosis  map ) PMID:14614132
a_re721:( Apoptosis  map ) PMID:12176997
a_re1149( Apoptosis  map ):
PMID:12441346
in murine L929 cell line, RIPK1 is a HSP90 client protein

HSP90*@default

References
d_re120( DNA repair  map ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141
d_re523( DNA repair  map ):
HSP90 redirects BRCA1 to degradation, inhibits HR and G2/M chechpoint, increases sensitivity to cross-linking agents
PMID:22869732
d_re525( DNA repair  map ):
HSP90 redirects FANCA to degradation, inhibits Fanconi pathway and increases sensitivity to cross-linking agents
PMID:17327415

HSP90*|​hm2@Cytoplasm

References
c_re192:( Cell cycle  map ) PMID:10385618, PMID:10498883


Modifications:
In compartment: Cytoplasm
  1. HSP90*@Cytoplasm map

  2. HSP90*|​hm2@Cytoplasm map

In compartment: default

  1. HSP90*@default map

Participates in complexes:
In compartment: Cytoplasm

  1. APAF1:​HSP90*@Cytoplasm map

  2. CDC37:​HSP90*|​hm2@Cytoplasm map
  3. CDC37:​HSP90*|​hm2@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. HSP90AA1@Cytoplasm map map HSP90*@Cytoplasm map

  2. HSP90AA2@Cytoplasm map map HSP90*@Cytoplasm map
  3. HSP90AB1@Cytoplasm map map HSP90*@Cytoplasm map
  4. APAF1@Cytoplasm map + HSP90*@Cytoplasm map map APAF1:​HSP90*@Cytoplasm map
  5. HSP90*@Cytoplasm map map HSP90*|​hm2@Cytoplasm map
  6. HSP90*|​hm2@Cytoplasm map + CDC37:​CDK4|​NF_don@Cytoplasm map map CDC37:​HSP90*|​hm2@Cytoplasm map
  7. CDC37:​HSP90*|​hm2@Cytoplasm map map CDK4@Cytoplasm map + CDC37:​HSP90*|​hm2@Cytoplasm map
  8. AKT1|​T450_emp|​S473_emp|​S129_pho@Cytoplasm map + HSP90*@Cytoplasm map map s_s_akt1_s132

As Catalyser:

  1. RIPK1|​unfolded@Cytoplasm map map RIPK1@Cytoplasm map

  2. HIF1A|​P564_hyd@Cytoplasm map map HIF1A|​ubi|​P564_hyd@Cytoplasm map
  3. BIRC5@Cytoplasm map map degraded
  4. AKT*|​S473_unk|​T308_unk@Cytoplasm map map AKT*|​S473_unk|​T308_unk|​unfolded@Cytoplasm map
  5. G2 phase@default map map M phase@default map
  6. BRCA1@default map map BRCA1|​ubi@default map
  7. FANCA@default map map FANCA@default map

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