HSP70*

Protein HSP70* map

Identifiers
heat shock 70kDa protein 1A
HUGO:HSPA1A HGNC:5232 ENTREZ:3303 UNIPROT:P08107 GENECARDS:HSPA1A REACTOME:56682 KEGG:3303 ATLASONC:GC_HSPA1A WIKI:HSPA1A HUGO:HSPA1B HGNC:5233 ENTREZ:3304 UNIPROT:P08107 GENECARDS:HSPA1B REACTOME:56682 KEGG:3304 ATLASONC:GC_HSPA1B WIKI:HSPA1B
heat shock 70kDa protein 1B
HUGO:HSPA1B HGNC:5233 ENTREZ:3304 UNIPROT:P08107 GENECARDS:HSPA1B REACTOME:56682 KEGG:3304 ATLASONC:GC_HSPA1B WIKI:HSPA1B HUGO:HSPA1A HGNC:5232 ENTREZ:3303 UNIPROT:P08107 GENECARDS:HSPA1A REACTOME:56682 KEGG:3303 ATLASONC:GC_HSPA1A WIKI:HSPA1A
heat shock 70kDa protein 1-like
HUGO:HSPA1L HGNC:5234 ENTREZ:3305 UNIPROT:P34931 GENECARDS:HSPA1L KEGG:3305 ATLASONC:GC_HSPA1L WIKI:HSPA1L
“heat shock 70kD protein 1A”, HSPA1

Maps_Modules
 Apoptosis  map  / CASPASES  map
 Survival  map  / WNT_NON_CANONICAL  map

HSP70*@Cytoplasm

References
a_re482( Apoptosis  map ):
PMID:17377525
review on apoptosome formation
PMID:11864614
stoechiometry apoptosome
PMID:12522243
inhibition of apoptosome formation by prothymosin-alpha
PMID:15087373
in HT-29 colon adenocarcinoma cells, siRNA against ACHE prevents the APAF1:CYCS interaction and etoposide-induced
PMID:14622304
AFP positive influence on apoptosome assembly
PMID:18439902
CAS PHAPI and HSP70 enhance apoptosome formation and caspase activation
a_re486( Apoptosis  map ):
PMID:10934467
in 293, HeLa and Jurkat cells, interaction HSP70 – APAF1
in vitro, the interaction is ATP dependent
HSP70 interactions competes for oligomerization and formation of the apoptosome
PMID:10934466
in vitro, HSP70 blocks the recruitment of CASP9 into the apoptosome by binding to APAF1
a_re733( Apoptosis  map ):
PMID:11533664
in vitro, HSP70 binds to AIF and inhibits its chromatin condensation activity
in MEFs that are deficient for apaf1, HSP70 protects from serum withdrawal induced cell death
in MEFs, HSP70 protects from cell death induced by the ectopic expression of a constitutively active AIF
a_re1163:( Apoptosis  map ) PMID:20111001


Modifications:
In compartment: Cytoplasm
  1. HSP70*@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. APAF1:​HSP70*@Cytoplasm map

  2. HSP70*:​cleaved~AIFM1*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. APAF1@Cytoplasm map + HSP70*@Cytoplasm map map APAF1:​HSP70*@Cytoplasm map

  2. HSP70*@Cytoplasm map + cleaved~AIFM1*@Cytoplasm map map HSP70*:​cleaved~AIFM1*@Cytoplasm map
  3. APC@Cytoplasm map + HTID1_50_48_kDa_isoform*@Cytoplasm map + HSP70*@Cytoplasm map + DVL*@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map + AXIN*@Cytoplasm map + HSC70*@Cytoplasm map map AXIN*:​DVL*:​HSC70*:​HTID1_50_48_kDa_isoform*@Cytoplasm map

As Catalyser:

  1. Lysosome membrane~integrity@Lysosome map + hydroxyl@Cytoplasm map map LMP@Lysosome map

  2. Cytochrome_C*|​ferroheme@Cytoplasm map + (d)ATP@Cytoplasm map + APAF1@Cytoplasm map map (d)ATP:​APAF1:​Cytochrome_C*|​ferroheme@Cytoplasm map

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