HRK

Protein HRK map

Identifiers
harakiri, BCL2 interacting protein (contains only BH3 domain)
HUGO:HRK HGNC:5185 ENTREZ:8739 UNIPROT:O00198 GENECARDS:HRK KEGG:8739 ATLASONC:HRKID40865ch12q24 WIKI:HRK

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / MITOCH_METABOLISM  map
 Apoptosis  map  / MOMP_REGULATION  map

HRK@Cytoplasm

References
a_re613( Apoptosis  map ):
PMID:15031724
Y2H by Y2H and coIP
a p32 mutant defective for interaction with HRK fails to target HRK to mitochondria and protects against HRK mediated apoptosis
p32 proposed to anchor HRK to the mitochondria

HRK@Mitochondrial outer membrane

References
a_re613( Apoptosis  map ):
PMID:15031724
Y2H by Y2H and coIP
a p32 mutant defective for interaction with HRK fails to target HRK to mitochondria and protects against HRK mediated apoptosis
p32 proposed to anchor HRK to the mitochondria
a_re606( Apoptosis  map ):
PMID:9130713
PMID:10075695
in 293T, IP
a_re612( Apoptosis  map ):
Y2H with human cDNA


Modifications:
In compartment: Cytoplasm
  1. HRK@Cytoplasm map

In compartment: Mitochondrial outer membrane

  1. HRK@Mitochondrial outer membrane map

Participates in complexes:
In compartment: Mitochondrial outer membrane

  1. BCL2:​HRK@Mitochondrial outer membrane map

  2. BCL2-XL*:​HRK@Mitochondrial outer membrane map
  3. HRK:​MCL1|​S159_unk@Mitochondrial outer membrane map

Participates in reactions:
As Reactant or Product:

  1. HRK@Cytoplasm map map HRK@Mitochondrial outer membrane map

  2. rHRK@Nucleus map map HRK@Cytoplasm map
  3. HRK@Mitochondrial outer membrane map + BCL2-XL*@Mitochondrial outer membrane map map BCL2-XL*:​HRK@Mitochondrial outer membrane map
  4. HRK@Mitochondrial outer membrane map + BCL2|​pho@Mitochondrial outer membrane map map BCL2:​HRK@Mitochondrial outer membrane map
  5. HRK@Mitochondrial outer membrane map + MCL1|​S159_unk@Mitochondrial outer membrane map map HRK:​MCL1|​S159_unk@Mitochondrial outer membrane map
  6. HRK@Cytoplasm map map HRK@Mitochondrial outer membrane map

As Catalyser:

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