Gene HR_DNA_st2* map

Resected DNA with double strand break

 DNA repair  map  / HR  map


d_re114( DNA repair  map ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
For role of BLM:TOP3:RMI1 complex in the HR resection step:
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
For inhibition of HR by RECQ5:
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
d_re165( DNA repair  map ):
Link between Fanconi pathway and HR.
Fanconi pathway is a coordination of NER, TLS and HR
POLH activates D-loop extension. PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
For role of SMARCAL1/RPA in stalled replication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862
d_re110( DNA repair  map ):
Phosphorylation by ATM and ATR at T847, S327
Phosphorylation at S327 by ATM and ATR are essential for shift from A_NHEJ to HR
Phosphorylation by CDC2(CDK1) in cell cycle dep manner to shift from C_NHEJ ot HR at: Ser 267
This phosphorylation allows resection that initiates HR and blocks binding of Ku70/Ku80 complex that initiates C_NHEJ.
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
BRCA1 and CtIP interactions make shift from A_NHEJ and C_NHEJ toward HR
Resected DNA in HR is a positive trigger for amplification of the HR pathway (positive loop):
Only when CDKs are fully active, this fully activates HR during S and G2 phases:
PMID:18511906, PMID:18716619
d_re119( DNA repair  map ):
For inhibition of S-checkpoint by ATM:
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767
d_re136( DNA repair  map ):
Regulation of HR DNA repair foci formation regulation by UBc13:
For role of SMARCAL1/RPA in stalled relication fork repair and in the homologous recombination:
MCM8*/MCM9* colocolize at RAD51 filament and reqired for interstrand crosslinks repair
d_re215( DNA repair  map ):
If the cell is in G1 phase, the double strand break will be repeated by C_NHEJ, because there is no homologous template from sister chromatide. If the cell is in S/G2 phase, HR will take place.

In compartment: Nucleus
  1. gHR_DNA_st2*@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map

    2. gHR_DNA_st2*@Nucleus map map gHR_DNA_st3*@Nucleus map
    3. gFanconi_DNA_st4*@Nucleus map map gHR_DNA_st2*@Nucleus map

    As Catalyser:

    1. CTIP*|​emp@default map map CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map

    2. S phase@default map map G2 phase@default map
    3. gHR_DNA_st1*@Nucleus map map gC_NHEJ_DNA_st1*@Nucleus map

    Leave a Reply