HRAS

Protein HRAS map

Identifiers
v-Ha-ras Harvey rat sarcoma viral oncogene homolog
HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS
HRAS1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:9069260
Activated HRAS (GTP bound forn) is associated with the plasma membrane.
Inactive RAF1 is associated in the cytoplasm with YWHAB via S259 phosphorylation site and also binding site.
RAF1 has a RAS-binding Cysteine-rich domain (CRD) and an additional RAS-binding domain (RBD).
RAF1 binds activated HRAS via the RBD. This binding displaces YWHAB from Ser259 and unmasks the CRD.

HRAS@Cytoplasm

References
s_wnc4_re22( Survival  map ):
c-Raf; MEK1/2; ERK1/2;HRAS
PMID:19906679
TGF-b1 in airway smooth muscle cells
PMID:21908588


Modifications:
In compartment: Cytoplasm
  1. HRAS@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. GDP:​HRAS@Cytoplasm map

  2. GTP:​HRAS@Cytoplasm map
  3. GTP:​HRAS:​RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. GDP:​HRAS@Cytoplasm map map GTP:​HRAS@Cytoplasm map

  2. RAF1|​S259_pho|​S621_pho|​S_pho|​closed:​YWHAB@Cytoplasm map + GTP:​HRAS@Cytoplasm map map GTP:​HRAS:​RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytoplasm map + YWHAB@Cytoplasm map
  3. GTP:​HRAS:​RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytoplasm map + YWHAB@Cytoplasm map map GTP:​RAF1|​S259_pho|​S621_pho|​S_pho|​open:​YWHAB@Cytoplasm map
  4. GTP:​HRAS@Cytoplasm map map GDP:​HRAS@Cytoplasm map

As Catalyser:

  1. (PI3KC1-catalytic*:​PI3KC1-regulator*)|​active@Cytoplasm map map (PI3KC1-catalytic*:​PI3KC1-regulator*)|​active@Cytoplasm map

  2. TIAM1@Cytoplasm map map TIAM1@Cytoplasm map
  3. g_beta_-Catenin*@Nucleus map map r_beta_-Catenin*@Nucleus map

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