Protein HRAS

Identifiers
v-Ha-ras Harvey rat sarcoma viral oncogene homolog
HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS
HRAS1

Maps_Modules
 EMT   / EMT_REGULATORS 
 Survival   / WNT_NON_CANONICAL 

References
PMID:9069260
Activated HRAS (GTP bound forn) is associated with the plasma membrane.
Inactive RAF1 is associated in the cytoplasm with YWHAB via S259 phosphorylation site and also binding site.
RAF1 has a RAS-binding Cysteine-rich domain (CRD) and an additional RAS-binding domain (RBD).
RAF1 binds activated HRAS via the RBD. This binding displaces YWHAB from Ser259 and unmasks the CRD.

HRAS@Cytoplasm

References
s_wnc4_re22( Survival  ):
c-Raf; MEK1/2; ERK1/2;HRAS
PMID:19906679
TGF-b1 in airway smooth muscle cells
PMID:21908588

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Modifications:
In compartment: Cytoplasm

1. HRAS@Cytoplasm

Participates in complexes:
In compartment: Cytoplasm

1. GDP:​HRAS@Cytoplasm

2. GTP:​HRAS@Cytoplasm
3. GTP:​HRAS:​RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytoplasm

Participates in reactions:
As Reactant or Product:

1. GDP:​HRAS@Cytoplasm → GTP:​HRAS@Cytoplasm

2. RAF1|​S259_pho|​S621_pho|​S_pho|​closed:​YWHAB@Cytoplasm + GTP:​HRAS@Cytoplasm → GTP:​HRAS:​RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytoplasm + YWHAB@Cytoplasm
3. GTP:​HRAS:​RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytoplasm + YWHAB@Cytoplasm → GTP:​RAF1|​S259_pho|​S621_pho|​S_pho|​open:​YWHAB@Cytoplasm
4. GTP:​HRAS@Cytoplasm → GDP:​HRAS@Cytoplasm

As Catalyser:

1. (PI3KC1-catalytic*:​PI3KC1-regulator*)|​active@Cytoplasm → (PI3KC1-catalytic*:​PI3KC1-regulator*)|​active@Cytoplasm

2. TIAM1@Cytoplasm → TIAM1@Cytoplasm
3. g_beta_-Catenin*@Nucleus → r_beta_-Catenin*@Nucleus