HMGA2

Protein HMGA2 map

Identifiers
high mobility group AT-hook 2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression


Modifications:
In compartment: Nucleus
  1. HMGA2@Nucleus map

Participates in complexes:
In compartment: Nucleus

  1. HMGA2:​SMAD2_3*:​SMAD4@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. (SMAD3|​S423_pho|​S425_pho|​hm2:​SMAD4)|​active@Nucleus map + HMGA2@Nucleus map map HMGA2:​SMAD2_3*:​SMAD4@Nucleus map

As Catalyser:

  1. gSNAI1@Nucleus map map rSNAI1@Nucleus map

  2. gID1@Nucleus map map rID1@Nucleus map
  3. gSNAI2@Nucleus map map rSNAI2@Nucleus map
  4. gZEB1@Nucleus map map rZEB1@Nucleus map
  5. gZEB2@Nucleus map map rZEB2@Nucleus map
  6. gTWIST1@Nucleus map map rTWIST1@Nucleus map

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