HIPK2

Protein HIPK2 map

Identifiers
homeodomain interacting protein kinase 2
HUGO:HIPK2 HGNC:14402 ENTREZ:28996 UNIPROT:Q9H2X6 GENECARDS:HIPK2 KEGG:28996 ATLASONC:HIPK2ID40824ch7q34 WIKI:HIPK2
“homeodomain-interacting protein kinase 2″

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:12851404, PMID:11925430, PMID:19828042, PMID:17349959
HIPK2 is pre-dominantly present in the nucleus
PMID:18974774

HIPK2@Nucleus

References
a_re450( Apoptosis  map ):
PMID:15708980
in H1299 by HIPK2 upon UV
PMID:16984892
in vitro
in H1299 upon JNK1 sustained activation (ectopic expression, UV or cisPlatin, in COS7), by JNK
in MEFs upon UV, but not in JNK1 KO MEFs

HIPK2|​pho|​active@default

References
d_re34:( DNA repair  map ) PMID:19788416


Modifications:
In compartment: Nucleus
  1. HIPK2@Nucleus map

In compartment: default

  1. HIPK2@default map

  2. HIPK2|​pho|​active@default map

Participates in complexes:
In compartment: Nucleus

  1. AXIN*:​HIPK2@Nucleus map

  2. CTBP*:​HIPK2:​LEF_TCF*@Nucleus map
  3. AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. HIPK2@default map map HIPK2|​pho|​active@default map

  2. HIPK2@default map map degraded
  3. HIPK2@Nucleus map map p53 pathway@Nucleus map
  4. _beta_-Catenin*@Nucleus map + HIPK2@Nucleus map + CTBP*@Nucleus map + LEF_TCF*@Nucleus map map CTBP*:​HIPK2:​LEF_TCF*@Nucleus map
  5. HIPK2@Nucleus map map Apoptosis@Nucleus map
  6. HIPK2@Nucleus map map Metastasis@Nucleus map
  7. AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map map Apoptosis@Nucleus map
  8. AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map map p53-target genes@Nucleus map
  9. AXIN*@Nucleus map + p53*@Nucleus map + HIPK2@Nucleus map map AXIN*:​HIPK2@Nucleus map
  10. AXIN*:​HIPK2@Nucleus map map AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map

As Catalyser:

  1. p53*@Nucleus map map p53*|​S15_pho|​active@Nucleus map

  2. CTBP*@Nucleus map map CTBP*|​S422_pho@Nucleus map
  3. p53*@default map map p53*|​pho|​ace|​active@default map
  4. CTBP*@default map map CTBP*|​pho@default map
  5. JNK*@default map map JNK*|​pho|​active@default map
  6. gCyclinD*@Nucleus map map rCyclinD*@Nucleus map
  7. CTBP*@Nucleus map map CTBP*|​S422_pho@Nucleus map
  8. HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus map map HDAC1_2*:​LEF_TCF*|​pho:​TLE*:​WRE*@Nucleus map
  9. _beta_-Catenin*@Nucleus map map _beta_-Catenin*|​pho|​pho@Nucleus map
  10. NLK|​hm2@Cytoplasm map map NLK|​T286_pho|​hm2|​active@Cytoplasm map

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