HEY1

Gene HEY1 map

Identifiers
hes-related family bHLH transcription factor with YRPW motif 1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

gHEY1@Nucleus

References
e_re1363( EMT  map ):
PMID:14976548
TGFB stimulates two kinetically coordinated waves of activation of HEY1.
Immediate-early activation of HEY1 by TGFB is mediated directly by Smad3/4 binding at two distinct sequences in the distal HEY1 promoter region and does not require Notch signalling.
The Smad-dependent, Notch-independent immediate-early activation is followed by a second wave of HEY1 activation.
This second wave is mediated by classical Notch-dependent signalling induced through indirect and delayed induction of Jag1 synthesis by TGFB


Modifications:
In compartment: Nucleus
  1. gHEY1@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gHEY1@Nucleus map map rHEY1@Nucleus map

    As Catalyser:

      Leave a Reply