heme a

Simple molecule heme a map
heme a@Mitochondrial Matrix

Identifiers
CHEBI:24479 KEGGCOMPOUND:C15670 CAS:18535-39-2

Maps_Modules
 Apoptosis  map  / MITOCH_METABOLISM  map

References
a_re983:( Apoptosis  map ) from unipathway
a_re93( Apoptosis  map ):
PMID:15119951
SURF1 mutations are associated with Leigh syndrome (cytochrome oxidase deficiency)
PMID:11389896
SURF1 Homolog of Yeast (Shy) is necessary for COX assembly and stability
PMID:19625251
Paroccocus denitrificans SURF1 homologs were proposed to promote heme a insertion into COX subunit 1
a_re1447:( Apoptosis  map ) reactionType:is.a


Modifications:
In compartment: Mitochondrial Matrix
  1. heme a@Mitochondrial Matrix map

Participates in complexes:
In compartment: Mitochondrial inner membrane

  1. COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map

  2. COX4I2:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map

Participates in reactions:
As Reactant or Product:

  1. heme a@Mitochondrial Matrix map map heme@Mitochondrial Matrix map

  2. COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map + COX4I2@Mitochondrial inner membrane map + ATP@Mitochondrial Matrix map map COX4I2:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map + ADP@Mitochondrial Matrix map
  3. degraded + MT-CO1@Mitochondrial inner membrane map + COX5A@Mitochondrial inner membrane map + COX6A*@Mitochondrial inner membrane map + COX5B@Mitochondrial inner membrane map + COX7A*@Mitochondrial inner membrane map + heme a@Mitochondrial Matrix map + MT-CO3@Mitochondrial inner membrane map + Cu2+:​MT-CO2@Mitochondrial inner membrane map map COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map
  4. heme o@Mitochondrial Matrix map map heme a@Mitochondrial Matrix map

As Catalyser:

  1. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial Matrix map + O_sub_2_endsub_@Mitochondrial inner membrane map map Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial intermembrane space map

  2. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + O_sub_2_endsub_@Mitochondrial intermembrane space map map Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial intermembrane space map

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