HDAC1_2*:LEF_TCF*:TLE*:WRE*

Complex HDAC1_2*:LEF_TCF*:TLE*:WRE* map


Complex composition:

  1. WRE* map
  2. LEF_TCF* map
  3. TLE* map
  4. HDAC1_2* map




HDAC1_2*:​LEF_TCF*|​pho:​TLE*:​WRE*@Nucleus

Identifiers
NAME:HDAC1_2*:LEF_TCF*:TLE*:WRE*

References
PMID:11266540
s_wca3_re146( Survival  map ):
HIPK2 phosphorylates any TCF/LEF
PMID:21285352
s_wca3_re147( Survival  map ):
Phosphorylated TCF/LEF transcription factor dissociates and is replaced by another unphosphorylated one. For example TCF3 (repressor) is phosphorylated by HIPK2 and will dissociate from the complex and is replaced by TCF1.
s_s_wca3_re147( Survival  map ):

Confidence
REF=2 FUNC=3

HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus

Identifiers
NAME:HDAC1_2*:LEF_TCF*:TLE*:WRE*

References
PMID:11266540
s_wca3_re111:( Survival  map ) PMID:16510874
s_wca3_re147( Survival  map ):
Phosphorylated TCF/LEF transcription factor dissociates and is replaced by another unphosphorylated one. For example TCF3 (repressor) is phosphorylated by HIPK2 and will dissociate from the complex and is replaced by TCF1.
PMID:21285352
s_wca3_re7( Survival  map ):
The transcription complex containing P300 initiates transcription of genes that are involved in differentiation.
PMID:20920541
The repressor complex is is by default present on the enhancers of wnt-target genes
PMID:16510874
s_wca3_re40( Survival  map ):
Not sure if ubiquitination by XIAP is necessary for replacement of TLE by b-catenin upon canonical WNT signaling
PMID:22304967
s_wca3_re125( Survival  map ):
CBP-mediated transcription effects genes that are involved in stemm cell or progenitor cell maintenance and proliferation
Repressor complex is default present on the enhance of wnt-target genes
s_wca3_re146( Survival  map ):
HIPK2 phosphorylates any TCF/LEF
s_s_wca3_re125( Survival  map ):
s_s_wca3_re146( Survival  map ):

Confidence
REF=4 FUNC=3

HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus

Identifiers
NAME:HDAC1_2*:LEF_TCF*:TLE*:WRE*

References
PMID:11266540
s_wca3_re40( Survival  map ):
Not sure if ubiquitination by XIAP is necessary for replacement of TLE by b-catenin upon canonical WNT signaling
PMID:22304967
s_wca3_re6( Survival  map ):
PMID:16169192
B-catenin competes with TLE for Lef-1
PMID:15768032
CBP-and P300-mediated transcription different cell fates
PMID:20530697
(phosphorylated) C-JUN can bind to TCF4
PMID:18347071 PMID:16007074

Confidence
REF=5 FUNC=3


Modifications:
Participates in complexes:
In compartment: Nucleus
  1. HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus map

  2. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus map
  3. HDAC1_2*:​LEF_TCF*|​pho:​TLE*:​WRE*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. CTBP*:​HDAC1_2*:​LEF_TCF*:​WRE*@Nucleus map + TLE*@Nucleus map map CTBP*@Nucleus map + HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus map

  2. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus map + BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map map BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_emp|​ace|​ace@Nucleus map + HDAC1_2*:​TLE*|​ubi@Nucleus map
  3. BCL9:​KLF8|​K67_ace|​K93_ace|​K95_ace:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map + HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus map map BCL9:​KLF8|​K67_ace|​K93_ace|​K95_ace:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map + HDAC1_2*:​TLE*|​ubi@Nucleus map
  4. HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus map map HDAC1_2*:​LEF_TCF*|​pho:​TLE*:​WRE*@Nucleus map
  5. HDAC1_2*:​LEF_TCF*|​pho:​TLE*:​WRE*@Nucleus map + LEF_TCF*@Nucleus map map HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus map + LEF_TCF*|​pho@Nucleus map
  6. LEF_TCF*@Nucleus map + HDAC1_2*@Nucleus map + TLE*@Nucleus map + gWRE*@Nucleus map map HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus map
  7. HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus map map HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus map
  8. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus map + BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map + HDAC1_2*:​TLE*|​ubi@Nucleus map

As Catalyser:

  1. gGenes under control of _br_CBP-mediated transcription*@Nucleus map map rRNA@Nucleus map

  2. gGene under control of_br_ P300-mediated transcription*@Nucleus map map rRNA@Nucleus map

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