HCLK2*

Protein HCLK2* map

Identifiers
TEL2, telomere maintenance 2, homolog (S. cerevisiae)
Protein clk-2 homolog , HCLK2
HUGO:TELO2 HGNC:29099 ENTREZ:9894 UNIPROT:Q9Y4R8 GENECARDS:TELO2 KEGG:9894 WIKI:TELO2

Maps_Modules
 DNA repair  map  / S_PHASE_CHECKPOINT  map

References
PMID:19686080, PMID:19622404, PMID:18931676
For regulation of Fanconi pathway via cell cycle
PMID:18995830, PMID:17384638
For S-phase checkpoint
PMID:17384638, PMID:19793801
HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase
PMID:19282663, PMID:19622404

HCLK2*@default

References
d_re199( DNA repair  map ):
HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase:
PMID:19282663, PMID:19622404, PMID:18995830
d_re463( DNA repair  map ):
Arrests cell cycle in S-phase in response to stalled replication fork or ds breaks in DNA:
PMID:15459660, PMID:17384638, PMID:19793801


Modifications:
In compartment: default
  1. HCLK2*@default map

Participates in complexes:
In compartment: default

  1. ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@default map

  2. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@default map

Participates in reactions:
As Reactant or Product:

  1. HCLK2*@default map + FAAP24*@default map + FANCM@default map + ATR|​pho|​active@Nucleus map map ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@default map

  2. HCLK2*@default map + CLSPN|​pho@default map + ATRIP:​ATR|​pho@default map + CHEK1|​pho|​active@default map map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@default map

As Catalyser:

  1. S phase@default map map G2 phase@default map

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