H2AFX:MDC1

Complex H2AFX:MDC1 map


Complex composition:

  1. H2AFX map
  2. MDC1 map




H2AFX|​pho|​ubi:​MDC1|​pho@default

Identifiers
NAME:H2AFX:MDC1

Maps_Modules
 DNA repair  map  / G2_M_CHECKPOINT  map
 DNA repair  map  / HR  map

References
PMID:17303408, PMID:16377563
d_re114( DNA repair  map ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
PMID:18212739
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
PMID:20021983
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833
d_re136( DNA repair  map ):
Regulation of HR DNA repair foci formation regulation by UBc13:
PMID:17349954
For role of SMARCAL1/RPA in stalled relication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862
MCM8*/MCM9* colocolize at RAD51 filament and reqired for interstrand crosslinks repair
PMID:22771115

Confidence
REF=5 FUNC=5


Modifications:
Participates in complexes:
In compartment: default
  1. H2AFX|​pho|​ubi:​MDC1|​pho@default map

Participates in reactions:
As Reactant or Product:

  1. H2AFX|​pho|​ubi@default map + MDC1|​pho@default map map H2AFX|​pho|​ubi:​MDC1|​pho@default map

  2. ATM|​pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map + H2AFX|​pho|​ubi:​MDC1|​pho@default map map ATM|​pho|​S367_pho|​S1893_pho:​H2AFX|​pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map

As Catalyser:

  1. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map

  2. gHR_DNA_st2*@Nucleus map map gHR_DNA_st3*@Nucleus map

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