GTP:HRAS

Complex GTP:HRAS map


Complex composition:

  1. GTP map
  2. HRAS map




GTP:​HRAS@Cytoplasm

Identifiers
NAME:GTP:HRAS

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
e_re382( EMT  map ):
In general, growth factor stimulation leads to the activation of receptor tyrosine kinases and to the phosphorylation of the receptor tail.
The resultant phosphotyrosines form docking sites for adaptator proteins (e.g. GRB2 via its SH2 domain).
The SH3 domain of adaptator (e.g. GRB2) then binds to the proline-rich motifs in the GTP exchange factor (i.e. GEF) for RAS (e.g. SOS)
Via this process that GEF (e.g. SOS) is recruited to the membrane where it colocalizes with and activates Ras.
PMID:17673906
SHC1 gene has 3 corresponding protein isoforms: p66, p52 and p46
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 (p66 or p52) on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 (p66 or p52) association with Grb2 and Sos
e_re385( EMT  map ):
PMID:9069260
Activated HRAS (GTP bound forn) is associated with the plasma membrane.
Inactive RAF1 is associated in the cytoplasm with YWHAB via S259 phosphorylation site and also binding site.
RAF1 has a RAS-binding Cysteine-rich domain (CRD) and an additional RAS-binding domain (RBD).
RAF1 binds activated HRAS via the RBD. This binding displaces YWHAB from Ser259 and unmasks the CRD.
e_re835( EMT  map ):
Cross-talk between small GTPase signaling pathways.
PMID:12134164
PMID:7673236
HRAS activates TIAM1 which is a GEF for Rac1.
RalBP1 (which is an effector for RalA and RalB) inactivates Rac1

Confidence
REF=3 FUNC=0


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. GTP:​HRAS@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. GDP:​HRAS@Cytoplasm map map GTP:​HRAS@Cytoplasm map

  2. RAF1|​S259_pho|​S621_pho|​S_pho|​closed:​YWHAB@Cytoplasm map + GTP:​HRAS@Cytoplasm map map GTP:​HRAS:​RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytoplasm map + YWHAB@Cytoplasm map
  3. GTP:​HRAS@Cytoplasm map map GDP:​HRAS@Cytoplasm map

As Catalyser:

  1. (PI3KC1-catalytic*:​PI3KC1-regulator*)|​active@Cytoplasm map map (PI3KC1-catalytic*:​PI3KC1-regulator*)|​active@Cytoplasm map

  2. TIAM1@Cytoplasm map map TIAM1@Cytoplasm map

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