Simple molecule GTP
GTP@Mitochondrial Matrix

Identifiers
CHEBI:15996 KEGGCOMPOUND:C00044 CAS:86-01-1

Maps_Modules
 Apoptosis   / MITOCH_METABOLISM 

GTP@Cytoplasm

Identifiers
CHEBI:15996 KEGGCOMPOUND:C00044 CAS:86-01-1

Maps_Modules
 Apoptosis   / MITOCH_METABOLISM 

References
a_re1094:( Apoptosis  ) reactionType:is.a

GTP@Vaceolae

References
s_wca1_re25:( Survival  ) PMID:21606194 PMID:19705439

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Modifications:
In compartment: Cytoplasm

1. GTP@Cytoplasm

In compartment: Mitochondrial Matrix

1. GTP@Mitochondrial Matrix

In compartment: Vaceolae

1. GTP@Vaceolae

Participates in complexes:
In compartment: Cytoplasm

1. GTP:​HRAS@Cytoplasm

2. GTP:​RAC1@Cytoplasm
3. GTP:​RHOA@Cytoplasm
4. GTP:​RHOB@Cytoplasm
5. CDC42:​GTP@Cytoplasm
6. (GTP:​G_alpha_*)|​active@Cytoplasm
7. CDC42:​GTP:​PAR6*@Cytoplasm
8. GTP:​G_alpha_*:​PLC_beta_*@Cytoplasm
9. GTP:​RHOA:​RhoA_cytoskeletal_effectors*@Cytoplasm
10. GTP:​RHOB:​RhoB_cytoskeletal_effectors*@Cytoplasm
11. DIA*|​open:​GTP:​RHOA@Cytoplasm
12. GTP:​RHOA:​ROCK*|​open@Cytoplasm
13. GTP:​RAF1|​S259_pho|​S621_pho|​S_pho|​open:​YWHAB@Cytoplasm
14. GTP:​HRAS:​RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytoplasm

In compartment: Vaceolae

1. CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae

Participates in reactions:
As Reactant or Product:

1. GTP@Cytoplasm → purine ribonucleoside 5′-triphosphate@Cytoplasm

2. GDP@Cytoplasm + ATP@Cytoplasm → GTP@Cytoplasm + ADP@Cytoplasm
3. GTP@Cytoplasm + ATP@Cytoplasm + UTP@Cytoplasm + CTP@Cytoplasm → rRNA@Cytoplasm
4. succinyl-CoA@Mitochondrial Matrix + GDP@Mitochondrial Matrix → succinate@Mitochondrial Matrix + coenzyme A@Mitochondrial Matrix + GTP@Mitochondrial Matrix
5. RAC1@Cytoplasm → GTP:​RAC1@Cytoplasm
6. FZD*:​GDP:​G_alpha_*:​G_beta_*:​G_gamma_*@Cytoplasm + WNT*@Extracellular space + LRP5_6*@Cytoplasm → FZD*:​LRP5_6*:​WNT*@Cytoplasm + (GTP:​G_alpha_*)|​active@Cytoplasm + G_beta_*:​G_gamma_*@Cytoplasm
7. EDNRA:​GDP:​G_alpha_*:​G_beta_*:​G_gamma_*@Cytoplasm + Endothelin1*@Extracellular space → EDNRA:​Endothelin1*@Cytoplasm + G_beta_*:​G_gamma_*@Cytoplasm + (GTP:​G_alpha_*)|​active@Cytoplasm
8. (GTP:​G_alpha_*)|​active@Cytoplasm + PLC_beta_*@Cytoplasm → GTP:​G_alpha_*:​PLC_beta_*@Cytoplasm
9. GDP:​HRAS@Cytoplasm → GTP:​HRAS@Cytoplasm
10. RAF1|​S259_pho|​S621_pho|​S_pho|​closed:​YWHAB@Cytoplasm + GTP:​HRAS@Cytoplasm → GTP:​HRAS:​RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytoplasm + YWHAB@Cytoplasm
11. GTP:​HRAS:​RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytoplasm + YWHAB@Cytoplasm → GTP:​RAF1|​S259_pho|​S621_pho|​S_pho|​open:​YWHAB@Cytoplasm
12. GTP:​RAF1|​S259_pho|​S621_pho|​S_pho|​open:​YWHAB@Cytoplasm + ATP@Cytoplasm → RAF1|​S259_pho|​S621_pho|​Y340_pho|​Y341_pho|​open@Cytoplasm + ADP@Cytoplasm
13. GTP:​RHOA@Cytoplasm → Tight junctions@Extracellular space
14. GTP:​RHOA@Cytoplasm → GDP:​RHOA@Cytoplasm
15. GDP:​RHOA@Cytoplasm → GTP:​RHOA@Cytoplasm
16. GTP:​RHOA@Cytoplasm → Establishment of cell polarity@Nucleus
17. GTP:​RHOA@Cytoplasm → Stress fiber formation@Nucleus
18. ROCK*|​closed@Nucleus + GTP:​RHOA@Cytoplasm → GTP:​RHOA:​ROCK*|​open@Cytoplasm
19. GTP:​RHOA@Cytoplasm + DIA*|​closed@Cytoplasm → DIA*|​open:​GTP:​RHOA@Cytoplasm
20. GTP:​RHOB@Cytoplasm → GDP:​RHOB@Cytoplasm
21. GDP:​RHOB@Cytoplasm → GTP:​RHOB@Cytoplasm
22. GTP:​RHOA:​RhoA_cytoskeletal_effectors*@Cytoplasm → Cytoskeleton remodeling@Nucleus
23. GTP:​RHOB:​RhoB_cytoskeletal_effectors*@Cytoplasm → Cytoskeleton remodeling@Nucleus
24. GTP:​RHOA@Cytoplasm + RhoA_cytoskeletal_effectors*@Cytoplasm → GTP:​RHOA:​RhoA_cytoskeletal_effectors*@Cytoplasm
25. GTP:​RHOA:​RhoA_cytoskeletal_effectors*@Cytoplasm → Actin polymerization@Nucleus
26. GTP:​RHOB:​RhoB_cytoskeletal_effectors*@Cytoplasm → Actin polymerization@Nucleus
27. RhoA_B*@Cytoplasm → GTP:​RHOA@Cytoplasm
28. RhoA_B*@Cytoplasm → GTP:​RHOB@Cytoplasm
29. GDP:​RAC1@Cytoplasm → GTP:​RAC1@Cytoplasm
30. GTP:​RAC1@Cytoplasm → GDP:​RAC1@Cytoplasm
31. GTP:​RAC1@Cytoplasm → ARHGEF14*@Cytoplasm
32. GTP:​RHOB@Cytoplasm + RhoB_cytoskeletal_effectors*@Cytoplasm → GTP:​RHOB:​RhoB_cytoskeletal_effectors*@Cytoplasm
33. GTP:​RAC1@Cytoplasm → NCKAP1@Cytoplasm
34. GTP:​RAC1@Cytoplasm → CYFIP2@Cytoplasm
35. GTP:​RAC1@Cytoplasm + NCK1@Cytoplasm → NCK1:​RAC1@Cytoplasm
36. CDC42:​GDP@Cytoplasm → CDC42:​GTP@Cytoplasm
37. CDC42:​GTP@Cytoplasm → CDC42:​GDP@Cytoplasm
38. PAR6*@Cytoplasm + CDC42:​GTP@Cytoplasm → CDC42:​GTP:​PAR6*@Cytoplasm
39. CDC42:​GTP@Cytoplasm + CDC42EP*@Cytoplasm → CDC42:​CDC42EP*@Cytoplasm
40. GTP:​HRAS@Cytoplasm → GDP:​HRAS@Cytoplasm
41. GTP:​RAC1@Cytoplasm → Membrane spreading@Cytoplasm
42. HH Ligand:​PTCH*@Cytoplasm + G_alpha__sub_i_endsub_*:​G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*:​SMO@Cytoplasm + GTP@Cytoplasm → G_alpha__sub_i_endsub_*:​G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*:​HH Ligand:​PTCH*:​SMO@Cytoplasm + GDP@Cytoplasm
43. GDP:​RAC1@Cytoplasm + GTP@Cytoplasm → GTP:​RAC1@Cytoplasm + GDP@Cytoplasm
44. GTP:​RAC1@Cytoplasm → EMT@Cytoplasm
45. G_alpha__sub_i_endsub_*:​HH Ligand:​PTCH*:​SMO@Cytoplasm + GTP@Cytoplasm → G_alpha__sub_i_endsub_*:​Ligand:​PTCH*:​SMO@Cytoplasm + GDP@Cytoplasm
46. WNT*@default + CK1_epsilon_*:​E-Cadherin*:​LRP5_6*:​p120*@Vaceolae + s_s_wca1_s211 + GTP@Vaceolae + PRR*@Cytoplasm → CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae + GDP@Vaceolae
47. DVL*|​pho|​S139_emp|​S142_emp:​_beta_-Arrestin2*@Cytoplasm + CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae + AMER1*:​CK1_gamma_*:​PtdIns(4,5)-P2@Cytoplasm → AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae + s_s_wca1_s1187 + G_beta_*:​G_gamma_*@Cytoplasm
48. PTH@default + PTHR*@Cytoplasm + GTP@Cytoplasm + G_alpha__sub_s_endsub_*:​LRP6@Cytoplasm → G_alpha__sub_s_endsub_*:​LRP6:​PTH@Cytoplasm + GDP@Cytoplasm
49. LRP6|​S1544_pho|​T1548_pho@Cytoplasm + s_s_wnc1_s172 + GTP@Cytoplasm → G_alpha__sub_s_endsub_*:​LRP6|​S1544_pho|​T1548_pho@Cytoplasm + GDP@Cytoplasm + LRP6|​S1544_pho|​T1548_pho@Cytoplasm
50. WNT*@default + FZD*:​GDP:​G_alpha_*:​G_beta_*:​G_gamma_*@Cytoplasm + GTP@Cytoplasm → s_s_wnc1_s240 + GDP@Cytoplasm
51. GTP:​RAC1@Cytoplasm + PLC-_beta_*@Cytoplasm → s_s_wnc1_s288
52. ROR2@Cytoplasm + FZD*:​GDP:​G_alpha_*:​G_beta_*:​G_gamma_*@Cytoplasm + WNT*@default + GTP@Cytoplasm + CK1_epsilon_*@Cytoplasm + CTHRC1@Cytoplasm + SYN4*@Cytoplasm + PRICKLE1|​pho:​VANGL*@Cytoplasm + PRR*@Cytoplasm → CK1_epsilon_*:​CTHRC1:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*@Cytoplasm + GDP@Cytoplasm
53. G_alpha__sub_13q_endsub_*:​PAR1_sub_TRUNC_endsub_*@Cytoplasm + GTP@Cytoplasm + _beta_-Arrestin*@Cytoplasm → G_alpha__sub_13q_endsub_*:​PAR1_sub_TRUNC_endsub_*:​_beta_-Arrestin*@Cytoplasm + GDP@Cytoplasm

As Catalyser:

1. (PI3KC1-catalytic*:​PI3KC1-regulator*)|​active@Cytoplasm → (PI3KC1-catalytic*:​PI3KC1-regulator*)|​active@Cytoplasm

2. PI(4,5)P2@Cytoplasm → I(1,4,5)P3@Cytoplasm + DAG@Cytoplasm
3. LEF1_TCF3_4*@Nucleus + _beta_-Catenin*@Cytoplasm → LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus
4. PAK*@Cytoplasm → PAK*|​pho|​active@Cytoplasm
5. MAP3K7_10_11*@Cytoplasm → MAP3K7_10_11*@Cytoplasm
6. PAR6*@Cytoplasm → PAR6*@Cytoplasm
7. ARFIP2@Cytoplasm → ARFIP2@Cytoplasm
8. PIP5K1*@Cytoplasm → PIP5K1*@Cytoplasm
9. BAIAP2@Cytoplasm → BAIAP2@Cytoplasm
10. TIAM1@Cytoplasm → TIAM1@Cytoplasm
11. PAK1@Cytoplasm → PAK1@Cytoplasm
12. PAK2@Cytoplasm → PAK2@Cytoplasm
13. PAK3@Cytoplasm → PAK3@Cytoplasm
14. PAK4@Cytoplasm → PAK4@Cytoplasm
15. CDC42BPA@Cytoplasm → CDC42BPA@Cytoplasm
16. WASP_NWASP*@Cytoplasm → WASP_NWASP*@Cytoplasm
17. MAP3K11@Cytoplasm → MAP3K11@Cytoplasm
18. PAK1@Cytoplasm + NISCH@Nucleus → NISCH:​PAK1@Cytoplasm
19. DVL*@Cytoplasm + s_s_wca1_s725 → DVL*:​KLHL*@Cytoplasm
20. s_s_wca1_s758 → JBN*:​_beta_-Catenin*@Cilium
21. JBN*:​_beta_-Catenin*@Cilium → s_s_wca1_s764
22. ATP6V0C_D*@Vaceolae → ATP6V0C_D*@Vaceolae