GRB2:LAMTOR2:MEK*:MP1*:RAF1:RAS*:RTK*:SOS*

Complex GRB2:LAMTOR2:MEK*:MP1*:RAF1:RAS*:RTK*:SOS* map


Complex composition:

  1. RAF1 map
  2. RTK* map
  3. GRB2 map
  4. SOS* map
  5. RAS* map
  6. LAMTOR2 map
  7. MEK* map
  8. MP1* map




GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes

Identifiers
NAME:GRB2:LAMTOR2:MEK*:MP1*:RAF1:RAS*:RTK*:SOS*

References
s_mpk1_re21( Survival  map ):
Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK map signalling pathway.
RasGTP and Sur-8 allow dephosphorylation of N-ter 14-3-3 binding site of Raf (not modelled) and thus its recruitment.
PMID:19289794 PMID:17496910
s_mpk1_re36( Survival  map ):
Activation of ERK pathway caused the dissociation of the MP1/ERK1 complex.
MP1 constitutively binds MEK1 but releases ERK / MAPK  map after activation. This turnover could provide an amplification mechanism that translates low MEK activity into sustained ERK / MAPK  map activation in which MP1 continues to supply MEK1 with inactive ERK / MAPK  map for phosphorylation.
PMID:15547943 PMID:16227978
s_mpk1_re22( Survival  map ):
Recruitment and phosphorylation of ERK1 on late endosomes.
PMID:17496910

Confidence
REF=2 FUNC=4


Modifications:
Participates in complexes:
In compartment: Late Endosomes
  1. GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map

Participates in reactions:
As Reactant or Product:

  1. RAF1@Cytoplasm map + GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map

  2. ERK*@Cytoplasm map + GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map
  3. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map + ERK*|​pho|​pho@Cytoplasm map

As Catalyser:

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