Protein GPI

Identifiers
glucose-6-phosphate isomerase
HUGO:GPI HGNC:4458 ENTREZ:2821 UNIPROT:P06744 GENECARDS:GPI REACTOME:55226 KEGG:2821 ATLASONC:GC_GPI WIKI:GPI

Maps_Modules
 Apoptosis   / APOPTOSIS_GENES 
 Apoptosis   / MITOCH_METABOLISM 

GPI|​hm2@Cytoplasm

References
a_re248( Apoptosis  ):
PMID:15637053
in human fibrosarcoma HT1080 cells, phosphorylation of GPI by CK2 decreases its enzymatic activity and (non-phosphorylatable or phospho-mimetic mutants)
in HT1080, knock-down of CK2 promotes GPI activity
in vitro, in HT1080 cells, phosphomimetic GPI mutant forms tetramers
in vitro, CK2 triggers GPI tetramerisation
PMID:11004567
in vitro CK2 mediated phosphorylation of GPI on S185
in HT1080 cells, Ser phosphorylation of GPI

GPI|​S185_pho|​hm4@Cytoplasm

References
a_re248( Apoptosis  ):
PMID:15637053
in human fibrosarcoma HT1080 cells, phosphorylation of GPI by CK2 decreases its enzymatic activity and (non-phosphorylatable or phospho-mimetic mutants)
in HT1080, knock-down of CK2 promotes GPI activity
in vitro, in HT1080 cells, phosphomimetic GPI mutant forms tetramers
in vitro, CK2 triggers GPI tetramerisation
PMID:11004567
in vitro CK2 mediated phosphorylation of GPI on S185
in HT1080 cells, Ser phosphorylation of GPI

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Modifications:
In compartment: Cytoplasm

1. GPI@Cytoplasm

2. GPI|​hm2@Cytoplasm
3. GPI|​S185_pho|​hm4@Cytoplasm

Participates in complexes:

Participates in reactions:
As Reactant or Product:

1. rGPI@Nucleus → GPI@Cytoplasm

2. GPI|​hm2@Cytoplasm → GPI|​S185_pho|​hm4@Cytoplasm
3. GPI@Cytoplasm → GPI|​hm2@Cytoplasm

As Catalyser:

1. glucose-6P@Cytoplasm → fructose-6P@Cytoplasm