GPCR*:GRK*:_beta_-Arrestin2*

Complex GPCR*:GRK*:_beta_-Arrestin2* map


Complex composition:

  1. _beta_-Arrestin2* map
  2. GRK* map
  3. GPCR* map




GPCR*|​pho:​GRK*:​_beta_-Arrestin2*@Plasma Membrane

Identifiers
NAME:GPCR*:GRK*:_beta_-Arrestin2*

References
s_mpk1_re61( Survival  map ):
Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN.
PMID:11226259
s_mpk1_re62( Survival  map ):
The component kinases of the ERK cascade Raf-1 MEK and ERK assemble using beta-ARRESTIN as a scaffold and leading to activation of ERK. Endocytosis of these receptor/beta-ARRESTIN complexes by clathrin-coated pits results in the targeting of activated ERK to endosomal vesicles.
The beta-ARRESTIN occupied receptor undergoes internalisation into early endosomes. At the early endosome stage beta-ARRESTIN recruits both MEK1/2 and ERK1/2 and is likely to facilitate their activation upon GPCR stimulation.
PMID:11226259 PMID:19565474

Confidence
REF=1 FUNC=3


Modifications:
Participates in complexes:
In compartment: Plasma Membrane
  1. GPCR*|​pho:​GRK*:​_beta_-Arrestin2*@Plasma Membrane map

Participates in reactions:
As Reactant or Product:

  1. GPCR*|​pho:​GRK*@Plasma Membrane map + _beta_-Arrestin2*@Cytoplasm map map GPCR*|​pho:​GRK*:​_beta_-Arrestin2*@Plasma Membrane map

  2. GPCR*|​pho:​GRK*:​_beta_-Arrestin2*@Plasma Membrane map + ERK*@Cytoplasm map + RAF1@Cytoplasm map + MEK*@Cytoplasm map map ERK*|​pho|​pho:​GPCR*:​GRK*:​MEK*|​pho|​pho:​RAF1|​pho:​_beta_-Arrestin2*@Early Endosomes map

As Catalyser:

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