s_mpk1_re61( Survival ):
Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN.
s_mpk1_re62( Survival ):
The component kinases of the ERK cascade Raf-1 MEK and ERK assemble using beta-ARRESTIN as a scaffold and leading to activation of ERK. Endocytosis of these receptor/beta-ARRESTIN complexes by clathrin-coated pits results in the targeting of activated ERK to endosomal vesicles.
The beta-ARRESTIN occupied receptor undergoes internalisation into early endosomes. At the early endosome stage beta-ARRESTIN recruits both MEK1/2 and ERK1/2 and is likely to facilitate their activation upon GPCR stimulation.
Participates in complexes:
In compartment: Plasma Membrane
Participates in reactions:
As Reactant or Product:
- GPCR*|pho:GRK*@Plasma Membrane + _beta_-Arrestin2*@Cytoplasm → GPCR*|pho:GRK*:_beta_-Arrestin2*@Plasma Membrane
- GPCR*|pho:GRK*:_beta_-Arrestin2*@Plasma Membrane + ERK*@Cytoplasm + RAF1@Cytoplasm + MEK*@Cytoplasm → ERK*|pho|pho:GPCR*:GRK*:MEK*|pho|pho:RAF1|pho:_beta_-Arrestin2*@Early Endosomes