GPCR*:GRK*

Complex GPCR*:GRK* map


Complex composition:

  1. GRK* map
  2. GPCR* map




GPCR*|​pho:​GRK*@Plasma Membrane

Identifiers
NAME:GPCR*:GRK*

References
s_mpk1_re85( Survival  map ):
Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN.
PMID:11226259

Confidence
REF=1 FUNC=3

GPCR*:​GRK*@Early Endosomes

Identifiers
NAME:GPCR*:GRK*

References
s_mpk1_re86( Survival  map ):
The internalised GPCR receptor will finally be recycled into the cell membrane or be sent to lysosome for degradation (not modelled).
PMID:19565474

Confidence
REF=0 FUNC=3


Modifications:
Participates in complexes:
In compartment: Early Endosomes
  1. GPCR*:​GRK*@Early Endosomes map

In compartment: Plasma Membrane

  1. GPCR*|​pho:​GRK*@Plasma Membrane map

Participates in reactions:
As Reactant or Product:

  1. GPCR*|​pho:​GRK*@Plasma Membrane map + _beta_-Arrestin2*@Cytoplasm map map GPCR*|​pho:​GRK*:​_beta_-Arrestin2*@Plasma Membrane map

  2. GPCR*@Plasma Membrane map + GRK*@Cytoplasm map map GPCR*|​pho:​GRK*@Plasma Membrane map
  3. ERK*|​pho|​pho:​GPCR*:​GRK*:​MEK*|​pho|​pho:​RAF1|​pho:​_beta_-Arrestin2*@Early Endosomes map map GPCR*:​GRK*@Early Endosomes map + ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map + RAF1@Cytoplasm map

As Catalyser:

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