GJB5

Protein GJB5 map

Identifiers
gap junction protein, beta 5, 31.1kDa
HUGO:GJB5 HGNC:4287 ENTREZ:2709 UNIPROT:O95377 GENECARDS:GJB5 REACTOME:53218 KEGG:2709 ATLASONC:GC_GJB5 WIKI:GJB5

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / GAP_JUNCTIONS  map

References
GJB5 is so-called Connexin 31.1
PMID:21777377
Cx31.1 (GJB5) is predominantly expressed in the testes and the skin epidermis.
Cx31.1 rarely form functional gap junction channels, either with itself or with other Cx isoforms.
Gap junctions play important roles in various physiologic functions such as regulation of cell proliferation, cell differentiation, tissue development and cell apoptosis.
In most cases, Cxs act as tumour suppressors: Gap junctions play an important role as tumour suppressors in maintaining cell differentiation and preventing transformation
Cx31.1 reduced tumour cell proliferation, anchorage-independent growth, migration and invasion.
Moreover, development of tumours in a xenograft model was suppressed by Cx31.1, suggesting that Cx31.1 may act as a tumour suppressor in NSCLC cell lines.
Expression of Cx31.1 reduced mesenchymal marker vimentin level and increased epithelial marker cytokeratin 18 level, indicating that Cx31.1 may regulate molecular pathways leading to a reverse of the EMT process.

GJB5@Cytoplasm

References
e_re56( EMT  map ):
GJB5 is so-called Connexin 31.1
PMID:21777377
Expression of Cx31.1 reduced mesenchymal marker vimentin level and increased epithelial marker cytokeratin 18 level, indicating that Cx31.1 may regulate molecular pathways leading to a reverse of the EMT process.
e_re671( EMT  map ):
Cx31.1 (GJB5) is predominantly expressed in the testes and the skin epidermis.
Cx31.1 rarely form functional gap junction channels, either with itself or with other Cx isoforms.
Gap junctions play important roles in various physiologic functions such as regulation of cell proliferation, cell differentiation, tissue development and cell apoptosis.
In most cases, Cxs act as tumour suppressors: Gap junctions play an important role as tumour suppressors in maintaining cell differentiation and preventing transformation
Cx31.1 reduced tumour cell proliferation, anchorage-independent growth, migration and invasion.
Moreover, development of tumours in a xenograft model was suppressed by Cx31.1, suggesting that Cx31.1 may act as a tumour suppressor in NSCLC cell lines.
e_re673( EMT  map ):
Further studies are required to investigate the mechanism by which Cx31.1 repress cyclin D3 expression
e_re675( EMT  map ):
Cx31.1overexpression slightly up-regulated E-cadherin expression, indicating that Cx31.1 overexpression mediate only a partial reversion to an epithelial phenotype of NSCLC cells.


Modifications:
In compartment: Cytoplasm
  1. GJB5@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. GJB5@Cytoplasm map map Cell migration@Cytoplasm map

    2. GJB5@Cytoplasm map map EMT@Cytoplasm map

    As Catalyser:

    1. rKRT18@Nucleus map map KRT18@Cytoplasm map

    2. rVimentin*@Nucleus map map Vimentin*@Cytoplasm map
    3. rCyclinD3*@Nucleus map map CyclinD3*@Cytoplasm map

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