GJB1

Protein GJB1 map

Identifiers
gap junction protein, beta 1, 32kDa
HUGO:GJB1 HGNC:4283 ENTREZ:2705 UNIPROT:P08034 GENECARDS:GJB1 REACTOME:53210 KEGG:2705 ATLASONC:GC_GJB1 WIKI:GJB1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / GAP_JUNCTIONS  map

References
GJB1 is so-called Connexin 32 or Cx32
PMID:9592087
Cx32 (GJB1) interacts with Cx26(GJB2), Cx46(GJA3), and Cx50(GJA8) but failing to do so with Cx40(GJA5).
PMID:15782139
Cx32 has a strong tumor-suppressive effect on a human metastatic renal cell carcinoma cell line.
Cx32-dependent inactivation of Src decreased the production of VEGF via the suppression of Stat3 activation
PMID:11978007
Cx32 Formation and / or Cx32-Mediated Intercellular Communication Induces Expression and Function of Tight Junctions in Hepatocytic Cell Line
PMID:19284610
Cx32, colocalizes with tight junction proteins ZO-1 and ZO-2 in rat hepatocytes, and small gap junction plaques were found within tight junction strands.
It was suggested that Cx32 can participate in the formation of functional tight junctions and in actin organization.

GJB1@Cytoplasm

References
e_re534( EMT  map ):
GJB1 is so-called Connexin 32 or Cx32
PMID:9592087
Cx32 (GJB1) interacts with Cx26(GJB2), Cx46(GJA3), and Cx50(GJA8) but failing to do so with Cx40(GJA5).
e_re548( EMT  map ):
PMID:15782139
Cx32 has a strong tumor-suppressive effect on a human metastatic renal cell carcinoma cell line.
Cx32-dependent inactivation of Src decreased the production of VEGF via the suppression of Stat3 activation
e_re651( EMT  map ):
PMID:11978007
Cx32 Formation and / or Cx32-Mediated Intercellular Communication Induces Expression and Function of Tight Junctions in Hepatocytic Cell Line
PMID:10581193
Induction of tight junctions in human connexin 32-transfected mouse hepatocytes: connexin 32 interacts with occludin.
PMID:17568974
Connexins induce and maintain tight junctions in epithelial cells.
e_re654( EMT  map ):
PMID:19284610
Cx32, colocalizes with tight junction proteins ZO-1 and ZO-2 in rat hepatocytes, and small gap junction plaques were found within tight junction strands.
It was suggested that Cx32 can participate in the formation of functional tight junctions and in actin organization.


Modifications:
In compartment: Cytoplasm
  1. GJB1@Cytoplasm map

  2. GJB1|​pho@Cytoplasm map

In compartment: Extracellular space

  1. GJB1@Extracellular space map

Participates in complexes:
In compartment: Cytoplasm

  1. GJB1:​ZO1_2*@Cytoplasm map

  2. GJB1:​v-SRC*@Cytoplasm map
  3. GJB1:​Occludin*@Cytoplasm map
  4. GJA3_8_GJB1_GJB2*:​GJB1@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. GJB1@Cytoplasm map + ATP@Cytoplasm map map GJB1|​pho@Cytoplasm map + ADP@Cytoplasm map

  2. GJA3_8_GJB1_GJB2*@Extracellular space map + GJB1@Cytoplasm map map GJA3_8_GJB1_GJB2*:​GJB1@Cytoplasm map
  3. GJB1@Cytoplasm map + v-SRC*@Cytoplasm map map GJB1:​v-SRC*@Cytoplasm map
  4. GJA3_8_GJB1_GJB2*@Extracellular space map map GJB1@Extracellular space map
  5. GJA3_8_GJB1_GJB2*:​GJB1@Cytoplasm map map Gap junctions@Cytoplasm map
  6. Occludin*@Cytoplasm map + GJB1@Cytoplasm map map GJB1:​Occludin*@Cytoplasm map
  7. GJB1:​Occludin*@Cytoplasm map map Tight junctions@Extracellular space map
  8. ZO1_2*@Cytoplasm map + GJB1@Cytoplasm map map GJB1:​ZO1_2*@Cytoplasm map
  9. GJB1:​ZO1_2*@Cytoplasm map map Tight junctions@Extracellular space map

As Catalyser:

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