GDP:HRAS

Complex GDP:HRAS map


Complex composition:

  1. HRAS map
  2. GDP map




GDP:​HRAS@Cytoplasm

Identifiers
NAME:GDP:HRAS

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
e_re382( EMT  map ):
In general, growth factor stimulation leads to the activation of receptor tyrosine kinases and to the phosphorylation of the receptor tail.
The resultant phosphotyrosines form docking sites for adaptator proteins (e.g. GRB2 via its SH2 domain).
The SH3 domain of adaptator (e.g. GRB2) then binds to the proline-rich motifs in the GTP exchange factor (i.e. GEF) for RAS (e.g. SOS)
Via this process that GEF (e.g. SOS) is recruited to the membrane where it colocalizes with and activates Ras.
PMID:17673906
SHC1 gene has 3 corresponding protein isoforms: p66, p52 and p46
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 (p66 or p52) on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 (p66 or p52) association with Grb2 and Sos

Confidence
REF=1 FUNC=0


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. GDP:​HRAS@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. GDP:​HRAS@Cytoplasm map map GTP:​HRAS@Cytoplasm map

  2. GTP:​HRAS@Cytoplasm map map GDP:​HRAS@Cytoplasm map

As Catalyser:

    Leave a Reply