GADD45A

Protein GADD45A map

Identifiers
Growth arrest and DNA-damage-inducible, alpha
HUGO:GADD45A HGNC:4095 ENTREZ:1647 UNIPROT:P24522 GENECARDS:GADD45A KEGG:1647 ATLASONC:GC_GADD45A WIKI:GADD45A

Maps_Modules
 DNA repair  map  / G2_M_CHECKPOINT  map
 DNA repair  map  / NER  map
 DNA repair  map  / BER  map

References
PMID:19004803
CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest
PMID:12124778, PMID:19652693, PMID:15917306
Role in BER
PMID:23485469

GADD45A@default

References
d_re8( DNA repair  map ):
GADD45 modulated and causes complex formation APE:PCNA. GADD is rgulated by p53:
PMID:17599061, PMID:23485469
d_re254( DNA repair  map ):
GADD45 interacts with PCNA and activates NER-only Global(GG-NER):
PMID:19652693, PMID:10779360


Modifications:
In compartment: default
  1. GADD45A@default map

Participates in complexes:
In compartment: Nucleus

  1. GADD45A:​PCNA@Nucleus map

In compartment: default

  1. CDK1:​CyclinB1*:​GADD45A@default map

Participates in reactions:
As Reactant or Product:

  1. rGADD45*@default map map GADD45A@default map

  2. GADD45A@default map + PCNA@default map map GADD45A:​PCNA@Nucleus map
  3. CDK1:​CyclinB1*@default map + GADD45A@default map map CDK1:​CyclinB1*:​GADD45A@default map

As Catalyser:

  1. gGG-NER_DNA_st2*@Nucleus map map gTC-NER_GG-NER_DNA_st3*@Nucleus map

  2. G2 phase@default map map M phase@default map
  3. gGG-NER_DNA_st1*@Nucleus map map gGG-NER_DNA_st2*@Nucleus map
  4. Mg2+@default map + APE*|​Thr233_pho|​ubi@default map + PCNA@default map + WRN@Nucleus map map APE*|​Thr233_pho|​ubi:​Mg2+:​PCNA:​WRN@default map

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