GADD45*

Gene GADD45* map

Identifiers
Growth arrest and DNA-damage-inducible, alpha
HUGO:GADD45A HGNC:4095 ENTREZ:1647 UNIPROT:P24522 GENECARDS:GADD45A KEGG:1647 ATLASONC:GC_GADD45A WIKI:GADD45A
DDIT1
growth arrest and DNA-damage-inducible beta
MYD118
HUGO:GADD45B HGNC:4096 ENTREZ:4616 UNIPROT:O75293 GENECARDS:GADD45B KEGG:4616 ATLASONC:GC_GADD45B WIKI:GADD45B
growth arrest and DNA-damage-inducible gamma
HUGO:GADD45G HGNC:4097 ENTREZ:10912 UNIPROT:O95257 GENECARDS:GADD45G KEGG:10912 ATLASONC:GC_GADD45G WIKI:GADD45G

Maps_Modules
 DNA repair  map  / G2_M_CHECKPOINT  map
 DNA repair  map  / NER  map
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:19004803
CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest
PMID:12124778, PMID:19652693, PMID:15917306
PMID:20025601
PMID:20673124

gGADD45*@default

References
d_re226( DNA repair  map ):
BRCA1 up-regulates transcription of GADD45 in p53 independed manner:
PMID:10367887, PMID:10962562
PMID:19004803, PMID:12496474
p53 enhances transcription of GADD45:
PMID:9892649, PMID:10779360
p53 regulated global genomic NER at the level of DNA damage recognition involving GADD45, XPC, DDB2:
PMID:12771027, PMID:9346961

gGADD45*@Nucleus

References
s_mpk1_re202( Survival  map ):
Expression of GADD45 is the culmination of a signaling pathway that requires prior expression of the tumor suppressor protein P53 which trans-activates the GADD45 gene.
PMID:11274345
s_mpk1_re253( Survival  map ):
Activation of P38 by TGF-β is mediated mainly by Smad-dependent GADD45β expression and by its subsequent activation of MTK1.
PMID:21614932
s_mpk1_re217:( Survival  map ) Translation
s_akt2_re79( Survival  map ):
PMID:17646672
PMID20673124


Modifications:
In compartment: Nucleus
  1. gGADD45*@Nucleus map

  2. gGADD45*@Nucleus map

In compartment: default

  1. gGADD45*@default map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gGADD45*@default map map rGADD45*@default map

    2. gGADD45*@Nucleus map map rGADD45*@Nucleus map
    3. p53*|​pho@Nucleus map map gGADD45*@Nucleus map
    4. gGADD45*@Nucleus map map GADD45*@Cytoplasm map
    5. s_s_mpk1_s1028 map gGADD45*@Nucleus map
    6. s_s_mpk1_s1027 map gGADD45*@Nucleus map

    As Catalyser:

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