GAB1

Protein GAB1 map

Identifiers
GRB2-associated binding protein 1
HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 GENECARDS:GAB1 REACTOME:147726 ATLASONC:GC_GAB1 WIKI:GAB1
GRB2-associated binding protein 2

Maps_Modules
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:11313945
PMID:11940581

GAB1@Cytoplasm

References
s_mpk1_re287( Survival  map ):
Grb2 recruits the docking protein Gab1 which is tyrosine phosphorylated by EGFR or FGFR leading to recruitment and activation of the PI3K-Akt cell survival pathway.
PMID:15567848
s_akt1_re145:( Survival  map ) PMID:11313945 PMID:11940581

GAB1|​Y977_pho|​Y989_pho@Cytoplasm

References
s_akt1_re145:( Survival  map ) PMID:11313945 PMID:11940581
s_akt1_re11( Survival  map ):
PMID:15584861
PMID:10648629


Modifications:
In compartment: Cytoplasm
  1. GAB1@Cytoplasm map

  2. GAB1@Cytoplasm map
  3. GAB1|​Y977_pho|​Y989_pho@Cytoplasm map

Participates in complexes:
In compartment: Endosome

  1. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map

In compartment: Lipid Raft

  1. GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map

Participates in reactions:
As Reactant or Product:

  1. p110*:​p85*@Cytoplasm map + s_s_akt1_s53 + PI3,4,5-P3@Lipid Raft map + RTK*@Cytoplasm map + GF@default map + RAS*@Cytoplasm map + GAB1|​Y977_pho|​Y989_pho@Cytoplasm map map GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map

  2. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map map Ubiquitination@Cytoplasm map
  3. GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map map GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map
  4. GAB1@Cytoplasm map map GAB1|​Y977_pho|​Y989_pho@Cytoplasm map
  5. GRB2@Cytoplasm map + GAB1@Cytoplasm map map s_s_mpk1_s1010

As Catalyser:

  1. PtdIns(4,5)-P2@Lipid Raft map map PI3,4,5-P3@Lipid Raft map

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