e_re703( EMT ):
p250GAP (so-called ARHGAP32 or p200RhoGAP) is a RhoGAP protein that is expressed predominantly in brain.
ARHGAP32 is associated with and phosphorylated by Fyn, a member of Src-family protein tyrosine kinase.
p250GAP is phosphorylated by Fyn in oligodendrocytes and Fyn activity is up-regulated during oligodendrocyte maturation.
e_re966( EMT ):
FYN is required for VAV1 phosphorylation and thus activation.
tyrosine phosphorylation of beta3 integrin and aVb3-mediated adhesion are required for VAV1 assocaition and Rho activation.
Vav1 associates with aVb3 upon cell adhesion to vitronectin
In compartment: Cytoplasm
Participates in complexes:
Participates in reactions:
As Reactant or Product: