FYN

Protein FYN map

Identifiers
FYN oncogene related to SRC, FGR, YES
HUGO:FYN HGNC:4037 ENTREZ:2534 UNIPROT:P06241 GENECARDS:FYN REACTOME:55160 KEGG:2534 ATLASONC:GC_FYN WIKI:FYN

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

FYN@Cytoplasm

References
e_re703( EMT  map ):
PMID:12788081
p250GAP (so-called ARHGAP32 or p200RhoGAP) is a RhoGAP protein that is expressed predominantly in brain.
ARHGAP32 is associated with and phosphorylated by Fyn, a member of Src-family protein tyrosine kinase.
p250GAP is phosphorylated by Fyn in oligodendrocytes and Fyn activity is up-regulated during oligodendrocyte maturation.
e_re966( EMT  map ):
PMID:9822663
FYN is required for VAV1 phosphorylation and thus activation.
PMID:15699036
tyrosine phosphorylation of beta3 integrin and aVb3-mediated adhesion are required for VAV1 assocaition and Rho activation.
Vav1 associates with aVb3 upon cell adhesion to vitronectin


Modifications:
In compartment: Cytoplasm
  1. FYN@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. Src family kinases*@Cytoplasm map map FYN@Cytoplasm map

    As Catalyser:

    1. PTPN11@Cytoplasm map map PTPN11|​pho|​active@Cytoplasm map

    2. ARHGAP32@Cytoplasm map map ARHGAP32|​Y_pho@Cytoplasm map
    3. VAV1@Cytoplasm map map VAV1@Cytoplasm map

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