FRAT1

Protein FRAT1 map

Identifiers
frequently rearranged in advanced T-cell lymphomas
HUGO:FRAT1 HGNC:3944 ENTREZ:10023 UNIPROT:Q92837 GENECARDS:FRAT1 REACTOME:54994 ATLASONC:GC_FRAT1 WIKI:FRAT1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map

FRAT1@Cytoplasm

References
e_re466( EMT  map ):
PMID:10428961
PMID:8666229
Wnt transduces their signals through DVL1 to inhibit GSK3B, leading to the accumulation of cytosolic CTNNB1 and activation of TCF/LEF1 transcription factors.
DVL1 interacts with AXIN1 and with Frat1.
Binding of AXIN1 to DVL1 reduces formation of the destruction complex APC/AXIN1.


Modifications:
In compartment: Cytoplasm
  1. FRAT1@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. AXIN1:​DVL1:​FRAT1@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. AXIN1@Cytoplasm map + DVL1:​FZD*:​LRP5_6*:​WNT*@Cytoplasm map + FRAT1@Cytoplasm map map AXIN1:​DVL1:​FRAT1@Cytoplasm map

As Catalyser:

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