FOXO3

Protein FOXO3 map

Identifiers
forkhead box O3
HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3
FKHRL1 FOXO3A

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:19564415
The transcription factor FOXO3, negatively regulated by binding to 14-3-3 protein family, induces MMP9 and MMP13 expression.
This explains the role of FOXO3 in promoting tumor invasion.
PMID:16288288
PMID:17646672

FOXO3@Nucleus

References
e_re65( EMT  map ):
PMID:10048576
The gene expressions of MMP-1, MMP-3, and MMP-9 and gelatinolytic activity of MMP-9 were significantly increased in high ETS-1 expression cells.
Low ETS-1 expression cells could not spread on a vitronectin substratum, and the phosphorylation of focal adhesion kinase was markedly impaired because of the reduced expression of integrin b3
PMID:16079281
MMP-9 transcription is activated in response to Snail expression
Oncogenic H-Ras (RasV12) synergistically co-operates with Snail in the induction of MMP-9 transcription and expression.
Phosphorylated Sp-1 is recruited to the MMP-9 promoter following activation of the Erk1/2 pathway
PMID:19564415
The transcription factor FOXO3, negatively regulated by binding to 14-3-3 protein family, induces MMP9 and MMP13 expression.
This explains the role of FOXO3 in promoting tumor invasion.

FOXO3|​S315_pho@Nucleus

References
s_akt1_re101:( Survival  map ) PMID:11154281

FOXO3|​T32_pho|​S253_pho|​S315_pho@Nucleus

References
s_akt1_re103:( Survival  map ) PMID:11154281

FOXO3|​pho|​pho|​pho@Nucleus

References
s_akt2_re8:( Survival  map ) PMID:11864996

FOXO3|​pho|​pho|​pho@Cytoplasm

References
s_akt2_re75:( Survival  map ) PMID:19321440

FOXO3|​pho|​pho|​pho|​ubi@Cytoplasm

References
s_akt2_re75:( Survival  map ) PMID:19321440

FOXO3|​S644_pho@Nucleus

References
s_akt2_re82:( Survival  map ) PMID15084260
s_akt2_re83:( Survival  map ) PMID:15084260

FOXO3|​S644_pho@Cytoplasm

References
s_akt2_re83:( Survival  map ) PMID:15084260

FOXO3|​S644_pho|​ubi@Cytoplasm

References
s_akt2_re127:( Survival  map ) PMID:15084260


Modifications:
In compartment: Cytoplasm
  1. FOXO3@Cytoplasm map

  2. FOXO3|​S644_pho@Cytoplasm map
  3. FOXO3|​S644_pho|​ubi@Cytoplasm map
  4. FOXO3|​pho|​pho|​pho@Cytoplasm map
  5. FOXO3|​pho|​pho|​pho|​ubi@Cytoplasm map

In compartment: Nucleus

  1. FOXO3@Nucleus map

  2. FOXO3|​pho@Nucleus map
  3. FOXO3|​S315_pho@Nucleus map
  4. FOXO3|​S644_pho@Nucleus map
  5. FOXO3|​pho|​pho|​pho@Nucleus map
  6. FOXO3|​T32_pho|​S253_pho|​S315_pho@Nucleus map

Participates in complexes:
In compartment: Nucleus

  1. 14-3-3*:​FOXO3@Nucleus map

  2. FOXO3|​pho:​promoter_region@Nucleus map
  3. FOXO3|​S644_pho:​promoter_region@Nucleus map
  4. FOXO3|​pho|​pho|​pho:​promoter_region@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. rFOXO3@Nucleus map map FOXO3@Cytoplasm map

  2. FOXO3@Nucleus map + RUNX3@Nucleus map map a_s1459
  3. FOXO3@Cytoplasm map map FOXO*@Cytoplasm map
  4. FOXO3@Nucleus map map FOXO*@Nucleus map
  5. 14-3-3*@Cytoplasm map + FOXO3@Nucleus map map 14-3-3*:​FOXO3@Nucleus map
  6. FOXO3@Nucleus map map FOXO3|​pho@Nucleus map
  7. FOXO3@Nucleus map map FOXO3|​S315_pho@Nucleus map
  8. FOXO3|​S315_pho@Nucleus map map FOXO3|​T32_pho|​S253_pho|​S315_pho@Nucleus map
  9. FOXO3|​T32_pho|​S253_pho|​S315_pho@Nucleus map + 14-3-3*@Cytoplasm map map s_s_akt1_s479
  10. FOXO3|​S644_pho@Cytoplasm map map FOXO3|​S644_pho|​ubi@Cytoplasm map
  11. s_s_akt2_s435 map FOXO3|​pho:​promoter_region@Nucleus map
  12. FOXO3|​pho:​promoter_region@Nucleus map map FOXO3|​pho|​pho|​pho:​promoter_region@Nucleus map
  13. FOXO3|​pho|​pho|​pho:​promoter_region@Nucleus map map FOXO3|​pho|​pho|​pho@Nucleus map + gpromoter_region@Nucleus map
  14. s_s_akt2_s28 map 14-3-3*@Cytoplasm map + FOXO3|​pho|​pho|​pho@Cytoplasm map
  15. FOXO3|​pho|​pho|​pho@Cytoplasm map map FOXO3|​pho|​pho|​pho|​ubi@Cytoplasm map
  16. FOXO3|​pho|​pho|​pho@Nucleus map + 14-3-3*@Nucleus map map s_s_akt2_s25
  17. s_s_akt2_s435 map FOXO3|​S644_pho:​promoter_region@Nucleus map
  18. FOXO3|​S644_pho:​promoter_region@Nucleus map map FOXO3|​S644_pho@Nucleus map + gpromoter_region@Nucleus map
  19. FOXO3|​S644_pho@Nucleus map map FOXO3|​S644_pho@Cytoplasm map
  20. FOXO3@Cytoplasm map map FOXO3|​pho@Nucleus map
  21. FOXO3|​pho@Nucleus map map Apoptosis@Cytoplasm map

As Catalyser:

  1. gp27KIP1*@Nucleus map map rp27KIP1*@Nucleus map

  2. gMMP13@Nucleus map map rMMP13@Nucleus map
  3. gMMP9@Nucleus map map rMMP9@Nucleus map
  4. gp27KIP1*@Nucleus map map rp27KIP1*@Nucleus map

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