FOXO1

Protein FOXO1 map

Identifiers
forkhead box O1
HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1
FKHR, “forkhead homolog in rhabdomyosarcoma”, FOXO1A

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:15668399

FOXO1@Nucleus

References
e_re250( EMT  map ):
PMID:11283613
Miz-1 regulates expression of p15INK4b
The Myc/Miz1 complex binds to the p15 promoter
Myc inhibits binding of p300 to Miz-1
Myc inhibits expression of p15INK4B by binding to Miz-1 (Myc represses p15INK4B by interacting with Miz1)
PMID:11283614
Disruption of the Myc-Miz1 interaction prevents repression of p15INK4B by Myc.
TGFB relieves Myc-mediated repression of p15INK4B by downregulating Myc bound to the p15INK4B transcriptional initiator region.
At the same time TGFB induces the formation of a Smad transcriptional complex that recognizes the p15INK4B promoter.
Is is proposed that by relieving the Myc-mediated repression of p15INK4B, TGFB allows this gene to be activated by the Smad complex.
TGFB signaling controls p15INK4B activation by 2 coupled events: transactivation and relief of repression.
PMID:10454538
Myc prevents inhibition of G1 CDKs by TGFB.
Inhibition of the p15 promoter by c-Myc.
Enforced expression of Myc abrogates p15INK4B induction and CDK inhibition by TGFB
Myc downregulation by TGFB is required for Activation of the p15Ink4b G1 Arrest Pathway
3 populations of endogenous CDK4: Latent pools (400 kDa, source of CDK4 for Cyclin D), Active CDK4-CyclinD complex, Inactive monomeric CDK4

FOXO1@Cytoplasm

References
a_re942:( Apoptosis  map ) reactionType:is.a

FOXO1|​T24_pho|​S256_pho|​S319_pho@Nucleus

References
s_akt2_re104:( Survival  map ) PMID:15668399
s_akt2_re159:( Survival  map ) PMID:17646672
s_akt2_re118:( Survival  map ) PMID:14664696
s_akt2_re121:( Survival  map ) PMID:11980723

FOXO1|​T24_pho|​S256_pho|​S319_pho@Cytoplasm

References
s_akt2_re120:( Survival  map ) PMID:14664696
s_akt2_re125:( Survival  map ) PMID:11980723 PMID:14664696
s_akt2_re91:( Survival  map ) PMID:15668399

FOXO1|​T24_pho|​S322_ubi|​S256_pho|​S319_pho@Cytoplasm

References
s_akt2_re91:( Survival  map ) PMID:15668399

FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_emp@Nucleus

References
s_akt2_re121:( Survival  map ) PMID:11980723

FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_pho@Nucleus

References
s_akt2_re122:( Survival  map ) PMID:11980723
s_akt2_re123:( Survival  map ) PMID:11980723 PMID:14664696

FOXO1|​pho|​emp|​pho@Cytoplasm

References
s_wnc2_re35:( Survival  map ) PMID:17662023


Modifications:
In compartment: Cytoplasm
  1. FOXO1@Cytoplasm map

  2. FOXO1|​pho|​emp|​pho@Cytoplasm map
  3. FOXO1|​pho|​pho|​pho@Cytoplasm map
  4. FOXO1|​T24_pho|​S256_pho|​S319_pho@Cytoplasm map
  5. FOXO1|​T24_pho|​S322_ubi|​S256_pho|​S319_pho@Cytoplasm map

In compartment: Nucleus

  1. FOXO1@Nucleus map

  2. FOXO1|​T24_pho|​S256_pho|​S319_pho@Nucleus map
  3. FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_emp@Nucleus map
  4. FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_pho@Nucleus map

Participates in complexes:
In compartment: Cytoplasm

  1. CRM1*:​FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_pho@Cytoplasm map

  2. (FOXO1|​pho|​emp|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map

In compartment: Nucleus

  1. FOXO1:​PPARGC1A@Nucleus map

  2. FOXO1|​T24_pho|​S256_pho|​S319_pho:​promoter_region@Nucleus map
  3. CRM1*:​FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_pho@Nucleus map
  4. (FOXO1|​pho|​emp|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. FOXO1:​PPARGC1A@Nucleus map map FOXO*@Nucleus map

  2. PPARGC1A@Nucleus map + FOXO1@Nucleus map map FOXO1:​PPARGC1A@Nucleus map
  3. FOXO1@Cytoplasm map map FOXO*@Cytoplasm map
  4. FOXO1@Nucleus map map FOXO*@Nucleus map
  5. FOXO1|​T24_pho|​S256_pho|​S319_pho:​promoter_region@Nucleus map map gpromoter_region@Nucleus map + FOXO1|​T24_pho|​S256_pho|​S319_pho@Nucleus map
  6. FOXO1|​T24_pho|​S256_pho|​S319_pho@Nucleus map + 14-3-3*@Nucleus map map s_s_akt2_s286
  7. s_s_akt2_s294 map 14-3-3*@Cytoplasm map + FOXO1|​T24_pho|​S256_pho|​S319_pho@Cytoplasm map
  8. FOXO1|​T24_pho|​S256_pho|​S319_pho@Nucleus map map FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_emp@Nucleus map
  9. FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_emp@Nucleus map map FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_pho@Nucleus map
  10. FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_pho@Nucleus map + CRM1*@Nucleus map map CRM1*:​FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_pho@Nucleus map
  11. CRM1*:​FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_pho@Nucleus map map CRM1*:​FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_pho@Cytoplasm map
  12. CRM1*:​FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_pho@Cytoplasm map map FOXO1|​T24_pho|​S256_pho|​S319_pho@Cytoplasm map + CRM1*@Cytoplasm map
  13. FOXO1@Nucleus map + RUNX2@Nucleus map map s_s_akt2_s432
  14. FOXO1@Nucleus map map FOXO1|​T24_pho|​S256_pho|​S319_pho@Nucleus map
  15. s_s_akt2_s228 map FOXO1|​T24_pho|​S256_pho|​S319_pho:​promoter_region@Nucleus map
  16. FOXO1|​T24_pho|​S256_pho|​S319_pho@Cytoplasm map map FOXO1|​T24_pho|​S322_ubi|​S256_pho|​S319_pho@Cytoplasm map
  17. PI3K Akt MTOR pathway@Cytoplasm map map FOXO1|​pho|​pho|​pho@Cytoplasm map
  18. FOXO1|​pho|​pho|​pho@Cytoplasm map map FOXO1|​pho|​emp|​pho@Cytoplasm map
  19. (PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map + FOXO1|​pho|​emp|​pho@Cytoplasm map map (FOXO1|​pho|​emp|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map
  20. (FOXO1|​pho|​emp|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map map (FOXO1|​pho|​emp|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Nucleus map

As Catalyser:

  1. gALAS1@Nucleus map map rALAS1@Nucleus map

  2. gp15INK4B*@Nucleus map map rp15INK4B*@Nucleus map

Leave a Reply