FOXO*

Protein FOXO* map

Identifiers
forkhead box O1
HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1
forkhead box O3
HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 DNA repair  map  / G1_S_CHECKPOINT  map

References
PMID:21708191, PMID:21613825, PMID:11154281, PMID:17940099, PMID:19380174, PMID:15084260

FOXO*|​pho|​pho@Cytoplasm

References
a_re331( Apoptosis  map ):
PMID:10102273
in vitro, by Akt, phosphosites identified by mutagenesis
in 293T using phosphoFOXO1 antibodies
PMID:18593906
in HEK293T, by PIM1s isoform, FOXO3 phosphorylated and inactivated. Phosphomutant of FOXO3 is not phosphorylated and the expression of a reporter gene is not inhibited.
a_re333:( Apoptosis  map ) logical:re333_s2093=FALSE

FOXO*@Cytoplasm

References
a_re319:( Apoptosis  map ) reactionType:is.a
a_re331( Apoptosis  map ):
PMID:10102273
in vitro, by Akt, phosphosites identified by mutagenesis
in 293T using phosphoFOXO1 antibodies
PMID:18593906
in HEK293T, by PIM1s isoform, FOXO3 phosphorylated and inactivated. Phosphomutant of FOXO3 is not phosphorylated and the expression of a reporter gene is not inhibited.

FOXO*@Nucleus

References
a_re316:( Apoptosis  map ) reactionType:is.a
a_re98( Apoptosis  map ):
PMID:18056423
p53 mediated upregulation of IGFBP1
in mouse liver
PMID:9707622
in HepG2, by HIF1
PMID:10102273
in 293T, by FOXO3, EMSA
a_re126( Apoptosis  map ):
PMID:14699081
in Saos-2, direct transactivation of NOXA by HIF1A during hypoxia, role of NOXA in hypoxia-induced cell death
PMID:16888645
in SH-EP, in NB15 neuroblastoma cell lines expressing a FOXO3-ER fusion, upon 4OHT. PMAIP knock down protects from apoptosis
PMID:12676992
in MEF by CTBP1 and CTBP2 (RT-PCR, double knocked out)
PMID:14684737
in NIH3T3, by E2F1
a_re131( Apoptosis  map ):
PMID:19211844
FOXO3 mediated inhibition
PMID:11714700
TP53 mediated inhibition
PMID:11965534
a_re152( Apoptosis  map ):
PMID:11050388
FOXO3
PMID:19494111
FOXO3, in Hep3B human hepatocarcinoma cell line
PMID:17604722
CHOP CEBPA
PMID:11495903
JNK
PMID:11301023
JNK, in neurons
in SH-EP, in NB15 neuroblastoma cell lines expressing a FOXO3-ER fusion, upon 4OHT. BIM knock down protects from apoptosis
PMID:18281283
in mouse lymphocytes with targeted expression of p52
in NIH3T3, the 3 major isoforms are upregulated by E2F1
a_re180( Apoptosis  map ):
PMID:16585195
in Hela cells, BNIP3 expression upon hypoxia is impaired by siRNA against HIF1
PMID:18054315
PMID:11559532
a_re230( Apoptosis  map ):
PMID:15766528
in murine fibroblasts, by IKKbeta
PMID:10492402
TNF or IL1 induction of cloned SOD2 full gene requires an intronic NFkB site
PMID:18280257
in human neuroblastoma by NFkB, upon all-trans-retinoic acid (ATRA)
PMID:12239572
in DLD-1 human colon carcinoma cells upon 4OHT mediated activation of ectopic an FOXO3-ER
in MEFs upon lentiviral expression of FOXO3 or FOXO4
in 293T upon LY294002, blocked by expression of a dominant negative FOXO3
a_re317( Apoptosis  map ):
in 293T, EMSA
in CCL23 chinese hamster lung fibroblast cell line, gene reporter
in cerebellar granule neurones and CCL23 cells, non phosphorylatable FOXO induces apoptosis that is blocked by a Fas decoy receptor
in Jurkat, non phosphorylatable FOXO induces apoptosis that is blocked by FAS or FADD mutations
a_re404( Apoptosis  map ):
PMID:18158893
by FOXO3
a_re408:( Apoptosis  map ) PMID:10783894
a_re1112( Apoptosis  map ):
PMID:14966295
in NIH3T3 by FOXO3

FOXO*|​unk@default

References
d_re415:( DNA repair  map ) PMID:17038621, PMID:15677884
d_re344:( DNA repair  map ) CHECKPOINT is p53_dependent_G1S_checkpoint
d_re399( DNA repair  map ):
Repression of p15INK4b expression by Myc through association with Miz-1:
PMID:9308237, PMID:11283613
Repression of pINK expression by BMI1:
PMID:17936558

FOXO*@default

References
d_re415:( DNA repair  map ) PMID:17038621, PMID:15677884


Modifications:
In compartment: Cytoplasm
  1. FOXO*@Cytoplasm map

  2. FOXO*|​pho|​pho@Cytoplasm map

In compartment: Nucleus

  1. FOXO*@Nucleus map

  2. FOXO*@Nucleus map

In compartment: default

  1. FOXO*@default map

  2. FOXO*|​unk@default map

Participates in complexes:
In compartment: Cytoplasm

  1. 14-3-3*|​unk:​FOXO*|​pho|​pho:​TSC1:​TSC2|​S939_don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. a_s1459 map FOXO*@Nucleus map

  2. FOXO3@Cytoplasm map map FOXO*@Cytoplasm map
  3. FOXO*@Cytoplasm map map FOXO*|​pho|​pho@Cytoplasm map
  4. FOXO*|​pho|​pho@Cytoplasm map map FOXO*@Cytoplasm map
  5. 14-3-3*|​unk@Cytoplasm map + FOXO*|​pho|​pho@Cytoplasm map map 14-3-3*|​unk:​FOXO*|​pho|​pho:​TSC1:​TSC2|​S939_don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytoplasm map
  6. FOXO1:​PPARGC1A@Nucleus map map FOXO*@Nucleus map
  7. FOXO1@Cytoplasm map map FOXO*@Cytoplasm map
  8. FOXO*@Cytoplasm map map FOXO*@Nucleus map
  9. FOXO3@Nucleus map map FOXO*@Nucleus map
  10. FOXO1@Nucleus map map FOXO*@Nucleus map
  11. FOXO*@default map map FOXO*|​unk@default map
  12. FOXO*|​unk@default map map FOXO*@default map

As Catalyser:

  1. gCyclinG2*@Nucleus map map rCyclinG2*@Nucleus map

  2. gPMAIP1@Nucleus map map rPMAIP1@Nucleus map
  3. gBIRC5@Nucleus map map rBIRC5@Nucleus map
  4. gBCL2L11@Nucleus map map rBCL2L11@Nucleus map
  5. gBNIP3@Nucleus map map rBNIP3@Nucleus map
  6. gSOD2@Nucleus map map rSOD2@Nucleus map
  7. gFASL*@Nucleus map map rFASL*@Nucleus map
  8. gCITED2@Nucleus map map rCITED2@Nucleus map
  9. gp27KIP1*@Nucleus map map rp27KIP1*@Nucleus map
  10. gIGFBP1@Nucleus map map rIGFBP1@Nucleus map
  11. gCIP/KIP*@default map map rCIP/KIP*@default map
  12. gINK4*@default map map rINK4*@default map

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