FOS:JUN

Complex FOS:JUN map


Complex composition:

  1. JUN map
  2. FOS map




FOS|​pho:​JUN|​pho@Nucleus

Identifiers
NAME:FOS:JUN

References
s_mpk1_re175( Survival  map ):
AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers.
PMID:11274345
s_mpk1_re187( Survival  map ):
JNK pathway negatively regulates ERK pathway by uncoupling ERK activation from MEK via activation of JUN transcriptional activity.
A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
PMID:12738796 PMID:18039929
s_mpk1_re189( Survival  map ):
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
PMID:18039929

Confidence
REF=1 FUNC=5


Modifications:
Participates in complexes:
In compartment: Nucleus
  1. FOS|​pho:​JUN|​pho@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. JUN|​pho@Nucleus map + FOS|​pho@Nucleus map map FOS|​pho:​JUN|​pho@Nucleus map

As Catalyser:

  1. ERK*|​pho|​pho@Cytoplasm map map ERK*@Cytoplasm map

  2. ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map map KSR1:​MEK*@Cytoplasm map + ERK*@Cytoplasm map
  3. ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map map MEK*:​SEF*@Cytoplasm map + ERK*@Cytoplasm map
  4. ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map map MEK*:​_beta_-Arrestin2*@Cytoplasm map + ERK*@Cytoplasm map
  5. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map + ERK*@Cytoplasm map + RAF1@Cytoplasm map

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