FOS

Protein FOS map

Identifiers
FBJ murine osteosarcoma viral oncogene homolog
HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100 GENECARDS:FOS REACTOME:54964 KEGG:2353 ATLASONC:GC_FOS WIKI:FOS
“v-fos FBJ murine osteosarcoma viral oncogene homolog”

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Survival  map  / MAPK  map
 Survival  map  / WNT_NON_CANONICAL  map

References
c-FOS is activated by ERK and RSK through phosphorylation.
PMID:16393692

FOS|​pho|​active@Nucleus

References
e_re1245( EMT  map ):
PMID:16716598
PMID:9588211
Endothelin1 is target gene of HIF1

FOS@Nucleus

References
s_mpk1_re216:( Survival  map ) Translation
s_mpk1_re177( Survival  map ):
Phosphorylation by both ERKs and their downstream RSKs can stabilise the c-FOS protein for several hours. The combination of these phosphorylations allows c-FOS sustained activity.
PMID:16393692
s_wnc3_re5:( Survival  map ) PMID:15657420
s_wnc3_re31( Survival  map ):
Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription
PMID15657416
Not sure if dissociation of calcineurin and ERK/MEK occurs

FOS|​pho@Nucleus

References
s_mpk1_re177( Survival  map ):
Phosphorylation by both ERKs and their downstream RSKs can stabilise the c-FOS protein for several hours. The combination of these phosphorylations allows c-FOS sustained activity.
PMID:16393692
s_mpk1_re175( Survival  map ):
AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers.
PMID:11274345

FOS@Nucleus

Maps_Modules
 Survival  map  / WNT_NON_CANONICAL  map

References
cFos, FosB, Fra1 and Fra2 bind to AP-1 regulatory elements
PMID:11402342


Modifications:
In compartment: Cytoplasm
  1. FOS@Cytoplasm map

  2. FOS|​pho|​active@Cytoplasm map

In compartment: Nucleus

  1. FOS@Nucleus map

  2. FOS@Nucleus map
  3. FOS|​pho@Nucleus map
  4. FOS|​pho|​active@Nucleus map

Participates in complexes:
In compartment: Nucleus

  1. FOS|​pho:​JUN|​pho@Nucleus map

  2. AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. FOS@Cytoplasm map map FOS|​pho|​active@Cytoplasm map

  2. FOS|​pho|​active@Cytoplasm map map FOS|​pho|​active@Nucleus map
  3. rFOS@Nucleus map map FOS@Cytoplasm map
  4. JUN|​pho@Nucleus map + FOS|​pho@Nucleus map map FOS|​pho:​JUN|​pho@Nucleus map
  5. FOS@Nucleus map map FOS|​pho@Nucleus map
  6. gFOS@Nucleus map map FOS@Nucleus map
  7. MAPK pathway@Cytoplasm map map FOS@Nucleus map
  8. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map + gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map map AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map + CNA*:​CNB*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map
  9. gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map + NFAT*@Nucleus map map AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map

As Catalyser:

  1. gEndothelin1*@Nucleus map map rEndothelin1*@Nucleus map

  2. ERK*|​pho|​pho@Cytoplasm map map ERK*@Cytoplasm map
  3. ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map map KSR1:​MEK*@Cytoplasm map + ERK*@Cytoplasm map
  4. ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map map MEK*:​SEF*@Cytoplasm map + ERK*@Cytoplasm map
  5. ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map map MEK*:​_beta_-Arrestin2*@Cytoplasm map + ERK*@Cytoplasm map
  6. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map + ERK*@Cytoplasm map + RAF1@Cytoplasm map
  7. gGPC6@Nucleus map map rGPC6@Nucleus map

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