Protein FKBP8

Identifiers
FK506 binding protein 8, 38kDa
HUGO:FKBP8 HGNC:3724 ENTREZ:23770 UNIPROT:Q14318 GENECARDS:FKBP8 KEGG:23770 ATLASONC:FKBP8ID40579ch19p13 WIKI:FKBP8

Maps_Modules
 Apoptosis   / AKT_MTOR 
 Apoptosis   / MOMP_REGULATION 

FKBP8@Cytoplasm

References
a_re998( Apoptosis  ):
PMID:17991864
FKBP8 antagonizes mTORC1, and mediates RHEB induced mTORC1 activation
a_re999( Apoptosis  ):
RHEB competes with mTOR for FKBP8 binding, thus alleviating FKBP8-mediated inhibition of mTORC1

FKBP8@Mitochondrial outer membrane

References
a_re1000( Apoptosis  ):
influenceDelete: reactants to re
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:10409669
CASP3 mediated cleavage of BCL2 in vitro and in HL60 cells or MCF7 with reconstituted CASP3 expression after exposure to staurosporine
no cleavage by CASP7
PMID:20139069
FKBP8 protects BCL2 from CASP3-mediated degradation

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Modifications:
In compartment: Cytoplasm

1. FKBP8@Cytoplasm

In compartment: Mitochondrial outer membrane

1. FKBP8@Mitochondrial outer membrane

Participates in complexes:
In compartment: Cytoplasm

1. FKBP8:​RHEB|​pre@Cytoplasm

2. FKBP8:​MLST8:​MTOR:​RPTOR|​unk@Cytoplasm

Participates in reactions:
As Reactant or Product:

1. MLST8:​MTOR:​RPTOR|​unk@Cytoplasm + FKBP8@Cytoplasm → FKBP8:​MLST8:​MTOR:​RPTOR|​unk@Cytoplasm

2. FKBP8@Cytoplasm + a_s2052 → FKBP8:​RHEB|​pre@Cytoplasm

As Catalyser:

1. BCL2|​unk@Mitochondrial outer membrane → cleaved~BCL2*@Mitochondrial outer membrane