FKBP8

Protein FKBP8 map

Identifiers
FK506 binding protein 8, 38kDa
HUGO:FKBP8 HGNC:3724 ENTREZ:23770 UNIPROT:Q14318 GENECARDS:FKBP8 KEGG:23770 ATLASONC:FKBP8ID40579ch19p13 WIKI:FKBP8

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / MOMP_REGULATION  map

FKBP8@Cytoplasm

References
a_re998( Apoptosis  map ):
PMID:17991864
FKBP8 antagonizes mTORC1, and mediates RHEB induced mTORC1 activation
a_re999( Apoptosis  map ):
RHEB competes with mTOR for FKBP8 binding, thus alleviating FKBP8-mediated inhibition of mTORC1

FKBP8@Mitochondrial outer membrane

References
a_re1000( Apoptosis  map ):
influenceDelete: reactants to re
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:10409669
CASP3 mediated cleavage of BCL2 in vitro and in HL60 cells or MCF7 with reconstituted CASP3 expression after exposure to staurosporine
no cleavage by CASP7
PMID:20139069
FKBP8 protects BCL2 from CASP3-mediated degradation


Modifications:
In compartment: Cytoplasm
  1. FKBP8@Cytoplasm map

In compartment: Mitochondrial outer membrane

  1. FKBP8@Mitochondrial outer membrane map

Participates in complexes:
In compartment: Cytoplasm

  1. FKBP8:​RHEB|​pre@Cytoplasm map

  2. FKBP8:​MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map + FKBP8@Cytoplasm map map FKBP8:​MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map

  2. FKBP8@Cytoplasm map + a_s2052 map FKBP8:​RHEB|​pre@Cytoplasm map

As Catalyser:

  1. BCL2|​unk@Mitochondrial outer membrane map map cleaved~BCL2*@Mitochondrial outer membrane map

Leave a Reply