Identifiers
FK506 binding protein 8, 38kDa
HUGO:FKBP8 HGNC:3724 ENTREZ:23770 UNIPROT:Q14318 GENECARDS:FKBP8 KEGG:23770 ATLASONC:FKBP8ID40579ch19p13 WIKI:FKBP8
Maps_Modules
Apoptosis / AKT_MTOR
Apoptosis / MOMP_REGULATION
FKBP8@Cytoplasm
References
a_re998( Apoptosis ):
PMID:17991864
FKBP8 antagonizes mTORC1, and mediates RHEB induced mTORC1 activation
a_re999( Apoptosis ):
RHEB competes with mTOR for FKBP8 binding, thus alleviating FKBP8-mediated inhibition of mTORC1
FKBP8@Mitochondrial outer membrane
References
a_re1000( Apoptosis ):
influenceDelete: reactants to re
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:10409669
CASP3 mediated cleavage of BCL2 in vitro and in HL60 cells or MCF7 with reconstituted CASP3 expression after exposure to staurosporine
no cleavage by CASP7
PMID:20139069
FKBP8 protects BCL2 from CASP3-mediated degradation
Modifications:
In compartment: Cytoplasm
In compartment: Mitochondrial outer membrane
Participates in complexes:
In compartment: Cytoplasm
Participates in reactions:
As Reactant or Product:
- MLST8:MTOR:RPTOR|unk@Cytoplasm
+ FKBP8@Cytoplasm
→
FKBP8:MLST8:MTOR:RPTOR|unk@Cytoplasm
- FKBP8@Cytoplasm
+ a_s2052 →
FKBP8:RHEB|pre@Cytoplasm
As Catalyser: