Fibronectin*

Protein Fibronectin* map

Identifiers
fibronectin 1
HUGO:FN1 HGNC:3778 ENTREZ:2335 UNIPROT:P02751 GENECARDS:FN1 REACTOME:54852 KEGG:2335 ATLASONC:GC_FN1 WIKI:FN1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map

References
PMID:2409071
Fibronectin is located on the apical and basal cell surfaces.

Fibronectin*@Cytoplasm

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

Fibronectin*@Extracellular space

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
e_re909( EMT  map ):
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens
PMID:12297042
Cell adhesion to components of the ECM is important in the angiogenesis
PMID:2153105
PMID:2786007
PMID:7639691
PMID:10809728
integrins are receptors for different ECM proteins: Collagen 1, 4; Laminin 1, 8; Fibronectin and Vitronectin
PMID:7522194
PMID:16195317
Interactions between integrins and the ECM proteins result in focal cell adhesion and cytoskeleton remodeling.
PMID:15866889
Fibronectin binds to alphaV/beta3 integrins supports persistent migration( directional cell migration)
Fibronectin binds to alpha5/beta1 integrins supports random migration.


Modifications:
In compartment: Cytoplasm
  1. Fibronectin*@Cytoplasm map

In compartment: Extracellular space

  1. Fibronectin*@Extracellular space map

Participates in complexes:
In compartment: Extracellular space

  1. Fibronectin*:​a5b1*_aVb3*@Extracellular space map

  2. Fibronectin partners*:​Fibronectin*@Extracellular space map

Participates in reactions:
As Reactant or Product:

  1. Collagen1 partners*@Extracellular space map map Fibronectin*@Extracellular space map

  2. Collagen2 partners*@Extracellular space map map Fibronectin*@Extracellular space map
  3. Fibronectin*@Extracellular space map + Fibronectin partners*@Extracellular space map map Fibronectin partners*:​Fibronectin*@Extracellular space map
  4. Fibronectin partners*:​Fibronectin*@Extracellular space map map Cell-matrix adhesions@Extracellular space map
  5. Fibronectin*@Extracellular space map map Truncated Fibronectin*@Extracellular space map
  6. rFibronectin*@Nucleus map map Fibronectin*@Cytoplasm map
  7. Fibronectin*@Cytoplasm map map Fibronectin*@Extracellular space map
  8. Fibronectin*@Extracellular space map + a5b1*_aVb3*@Extracellular space map map Fibronectin*:​a5b1*_aVb3*@Extracellular space map
  9. Fibronectin*:​a5b1*_aVb3*@Extracellular space map map (ITGA5:​ITGB1)|​active@Extracellular space map
  10. Fibronectin*:​a5b1*_aVb3*@Extracellular space map map (ITGAV:​ITGB3)|​active@Extracellular space map
  11. Fibronectin*:​a5b1*_aVb3*@Extracellular space map map Cell-matrix adhesions@Extracellular space map

As Catalyser:

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