FGFR1

Protein FGFR1 map

Identifiers
Fibroblas growth factors FGF
fibroblast growth factor receptor 1
FLT2 “fms-related tyrosine kinase 2″ KAL2
HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated.
PMID:17496910

FGFR1@Cytoplasm

References
e_re894( EMT  map ):
PMID:10551883
FGFR1 regulates activity of CDC42 by binding and phosphorylating thus inactivating BCL2.
Phosphorylated BCL2 binds to another CDC42_GAP, ARHGAP1 and neutralize the GAP activity of ARHGAP1 as well.

FGFR1|​hm2|​active@Cytoplasm

References
e_re1272( EMT  map ):
PMID:17673906
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 association with Grb2 and Sos
PMID:12767520
Upon IGF stimulation, the activated IGF1R recruits and directly phosphorylates SHC1, leading to cellular proliferation


Modifications:
In compartment: Cytoplasm
  1. FGFR1@Cytoplasm map

  2. FGFR1|​hm2|​active@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. FGFR family*@Cytoplasm map map FGFR1@Cytoplasm map

    2. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytoplasm map map FGFR1|​hm2|​active@Cytoplasm map

    As Catalyser:

    1. SHC1_p66_p52*@Cytoplasm map map SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytoplasm map

    2. PLC_gamma_*@Cytoplasm map map PLC_gamma_*|​pho|​active@Cytoplasm map
    3. FRS2@Cytoplasm map map FRS2|​pho|​active@Cytoplasm map
    4. BNIP2@Cytoplasm map map BNIP2|​pho@Cytoplasm map

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