Fibroblas growth factors FGF
fibroblast growth factor receptor 1
FLT2 “fms-related tyrosine kinase 2″ KAL2
HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1
RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated.
e_re894( EMT ):
FGFR1 regulates activity of CDC42 by binding and phosphorylating thus inactivating BCL2.
Phosphorylated BCL2 binds to another CDC42_GAP, ARHGAP1 and neutralize the GAP activity of ARHGAP1 as well.
e_re1272( EMT ):
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 association with Grb2 and Sos
Upon IGF stimulation, the activated IGF1R recruits and directly phosphorylates SHC1, leading to cellular proliferation
In compartment: Cytoplasm
Participates in complexes:
Participates in reactions:
As Reactant or Product:
- FGFR family*@Cytoplasm → FGFR1@Cytoplasm
- FGF family*|hm2:FGFR family*:Heparin|hm2@Cytoplasm → FGFR1|hm2|active@Cytoplasm